[HTML][HTML] Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on …

M Ayres Pereira, T Mandel Clausen, C Pehrson… - PLoS …, 2016 - journals.plos.org
During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the
placenta, causing health problems for both the mother and fetus. The specific adherence is …

[HTML][HTML] Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype

NK Viebig, E Levin, S Dechavanne, SJ Rogerson… - PloS one, 2007 - journals.plos.org
Infection with Plasmodium falciparum during pregnancy is one of the major causes of
malaria related morbidity and mortality in newborn and mothers. The complications of …

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A

NK Viebig, B Gamain, C Scheidig, C Lépolard… - EMBO …, 2005 - embopress.org
In high‐transmission regions, protective clinical immunity to Plasmodium falciparum
develops during the early years of life, limiting serious complications of malaria in young …

VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum

MF Duffy, AG Maier, TJ Byrne, AJ Marty… - Molecular and …, 2006 - Elsevier
Malaria during pregnancy causes serious disease that is associated with sequestration in
the placenta of Plasmodium falciparum infected erythrocytes that adhere to several host …

[HTML][HTML] Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

TM Clausen, S Christoffersen, M Dahlbäck… - Journal of Biological …, 2012 - ASBMB
Malaria is a major global health problem. Pregnant women are susceptible to infection
regardless of previously acquired immunity. Placental malaria is caused by parasites …

[HTML][HTML] Var2CSA minimal CSA binding region is located within the N-terminal region

A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …

[HTML][HTML] Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA

M Resende, MA Nielsen, M Dahlbäck, SB Ditlev… - Malaria Journal, 2008 - Springer
Background Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …

Identification of Multiple Chondroitin Sulfate A (CSA)–Binding Domains in the var2CSA Gene Transcribed in CSA-Binding Parasites

B Gamain, AR Trimnell, C Scheidig… - The Journal of …, 2005 - academic.oup.com
Malaria in pregnancy is a serious complication associated with parasitized erythrocyte (PE)
sequestration in the placenta. Recent work suggests that var genes could play an important …

Cytoadhesion of Plasmodium falciparum–infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced

H Rieger, HY Yoshikawa, K Quadt… - Blood, The Journal …, 2015 - ashpublications.org
Infections with the human malaria parasite Plasmodium falciparum during pregnancy can
lead to severe complications for both mother and child, resulting from the cytoadhesion of …

[HTML][HTML] Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library

N Sugiura, TM Clausen, T Shioiri, T Gustavsson… - Glycoconjugate …, 2016 - Springer
Placental malaria, a serious infection caused by the parasite Plasmodium falciparum, is
characterized by the selective accumulation of infected erythrocytes (IEs) in the placentas of …