Opioid drugs are important tools to alleviate pain of different origins, but they have strong
addictive potential and their abuse at higher doses often results in serious health …

Respiratory depression limits the use of opioid analgesia. Although well described clinically,
the specific mechanisms of opioid action on respiratory control centres in the brain have …

There has been increasing recognition of the problem of fatal opioid overdose. This review
examines the pharmacological basis of respiratory depression following opioid …

Opioid overdose, which is commonly associated with opioid induced respiratory depression,
is a problem with both therapeutic and illicit opioid use. While the central mechanisms …

Key points The main cause of death from opioid overdose is respiratory depression due to
the activation of µ‐opioid receptors (MORs). We conditionally deleted MORs from neurons in …

Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Respiratory depression is the proximal cause of death in opioid overdose, yet the
mechanisms underlying this potentially fatal outcome are not well understood. The goal of …

Background and Purpose Fentanyl overdose deaths have reached “epidemic” levels in
North America. Death in opioid overdose invariably results from respiratory depression. In …

Opioid-induced respiratory depression (OIRD), the primary cause of opioid-induced death, is
the neural depression of respiratory drive which, together with a decreased level of …

The opioid overdose death toll in the United States is an ongoing public health crisis. We
characterized the magnitude and duration of respiratory depression, the leading cause of …