Inflammation and oxidative stress are interlinked and interdependent processes involved in
many chronic diseases, including neurodegeneration, diabetes, cardiovascular diseases …

Mitochondrial dysfunction results in a series of defective cellular events, including
decreased adenosine triphosphate (ATP) production, enhanced reactive oxygen species …

Parkinson disease (PD) is a neurodegenerative disease characterized by progressive
dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) area. The …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative diseases in the elderly. The key histopathological features of these …

The downregulation of cannabinoid type-2 receptors (CB2R) have been reported in
numerous diseases including cardiovascular diseases (CVDs). The activation of CB2R has …

(E)-β-caryophyllene (BCP) is a bicyclic sesquiterpene widely distributed in the plant
kingdom, where it contributes a unique aroma to essential oils and has a pivotal role in the …

Natural products remain a crucial source of drug discovery for accessible and affordable
solutions for healthy aging. Centella asiatica (L.) Urb.(CA) is an important medicinal plant …

The link between mitochondrial dysfunction, redox impairment, and inflammation leads to
increased rates of brain cells loss in neurodegenerative diseases and in affective disorders …

Mitochondria are cytoplasmic organelles that regulate both metabolic and apoptotic
signaling pathways; their most highlighted functions include cellular energy generation in …

Growing evidence from neurodegenerative disease research supports an early pathogenic
role for mitochondrial dysfunction in affected neurons that precedes morphological and …