Nef secretion into extracellular vesicles or exosomes is conserved across human and simian immunodeficiency viruses
RP McNamara, LM Costantini, TA Myers, B Schouest… - MBio, 2018 - Am Soc Microbiol
Extracellular vesicles (EVs) or exosomes have been implicated in the pathophysiology of
infections and cancer. The negative regulatory factor (Nef) encoded by simian …
infections and cancer. The negative regulatory factor (Nef) encoded by simian …
[HTML][HTML] Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection
JV de Carvalho, RO de Castro, EZM da Silva… - PloS one, 2014 - journals.plos.org
Nef is an HIV-1 accessory protein that promotes viral replication and pathogenesis. A key
function of Nef is to ensure sustained depletion of CD4 and MHC-I molecules in infected …
function of Nef is to ensure sustained depletion of CD4 and MHC-I molecules in infected …
Genetic characterization of HIV type 1 Nef-induced vesicle secretion
SA Ali, MB Huang, PE Campbell, WW Roth… - AIDS research and …, 2010 - liebertpub.com
The HIV-1 Nef protein is known to be secreted, and our group has shown that Nef is
secreted from nef-transfected and HIV-1-infected cells in small exosome-like vesicles (d. 40 …
secreted from nef-transfected and HIV-1-infected cells in small exosome-like vesicles (d. 40 …
[HTML][HTML] Exosomes are unlikely involved in intercellular Nef transfer
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Several recent
studies including ours have demonstrated that Nef can be transferred to neighboring cells …
studies including ours have demonstrated that Nef can be transferred to neighboring cells …
HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells
M Lenassi, G Cagney, M Liao, T Vaupotič… - Traffic, 2010 - Wiley Online Library
The HIV accessory protein negative factor (Nef) is one of the earliest and most abundantly
expressed viral proteins. It is also found in the serum of infected individuals (Caby MP …
expressed viral proteins. It is also found in the serum of infected individuals (Caby MP …
HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals
AD Raymond, TC Campbell-Sims, M Khan… - AIDS research and …, 2011 - liebertpub.com
HIV-1 Nef has been demonstrated to be integral for viral persistence, infectivity, and the
acceleration of disease pathogenesis (AIDS) in humans. Nef has also been detected in the …
acceleration of disease pathogenesis (AIDS) in humans. Nef has also been detected in the …
[HTML][HTML] HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions
TD Campbell, M Khan, MB Huang, VC Bond… - Ethnicity & …, 2008 - ncbi.nlm.nih.gov
HIV-1 Nef is a major determinant in HIV-1 pathogenicity. However, its properties have mainly
been associated with its biochemical activities within the producer cell. Nef is also secreted …
been associated with its biochemical activities within the producer cell. Nef is also secreted …
Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release
Nef is secreted from infected cells in exosomes and is found in abundance in the sera of HIV-
infected individuals. Secreted exosomal Nef (exNef) induces apoptosis in uninfected CD4+ …
infected individuals. Secreted exosomal Nef (exNef) induces apoptosis in uninfected CD4+ …
[HTML][HTML] Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells
C Muratori, LE Cavallin, K Krätzel, A Tinari… - Cell host & …, 2009 - cell.com
The HIV Nef protein mediates endocytosis of surface receptors that correlates with disease
progression, but the link between this Nef function and HIV pathogenesis is not clear. Here …
progression, but the link between this Nef function and HIV pathogenesis is not clear. Here …
[HTML][HTML] HIV-1 nef changes the proteome of T cells extracellular vesicles depleting IFITMs and other antiviral factors
ME da Silva-Januário, CS da Costa, LA Tavares… - Molecular & Cellular …, 2023 - ASBMB
Extracellular vesicles (EVs) are biomolecule carriers for intercellular communication in
health and disease. Nef is a HIV virulence factor that is released from cells within EVs and is …
health and disease. Nef is a HIV virulence factor that is released from cells within EVs and is …