Real-time in vivo diagnosis of laryngeal carcinoma with rapid fiber-optic Raman spectroscopy

K Lin, W Zheng, CM Lim, Z Huang - Biomedical optics express, 2016 - opg.optica.org
We assess the clinical utility of a unique simultaneous fingerprint (FP)(ie, 800-1800 cm^− 1)
and high-wavenumber (HW)(ie, 2800-3600 cm^− 1) fiber-optic Raman spectroscopy for in …

[HTML][HTML] Real-time in vivo diagnosis of nasopharyngeal carcinoma using rapid fiber-optic Raman spectroscopy

K Lin, W Zheng, CM Lim, Z Huang - Theranostics, 2017 - ncbi.nlm.nih.gov
We report the utility of a simultaneous fingerprint (FP)(ie, 800-1800 cm-1) and high-
wavenumber (HW)(ie, 2800-3600 cm-1) fiber-optic Raman spectroscopy developed for real …

[HTML][HTML] Real-time in vivo cancer staging of nasopharyngeal carcinoma patients with rapid fiberoptic Raman endoscopy

C Shu, W Zheng, K Lin, CM Lim, Z Huang - Talanta, 2023 - Elsevier
Cancer staging is important to guide treatment and for prognostication. This work aims to
demonstrate the ability of rapid fiberoptic Raman endoscopy for real-time in vivo cancer …

Optical diagnosis of laryngeal cancer using high wavenumber Raman spectroscopy

K Lin, DLP Cheng, Z Huang - Biosensors and Bioelectronics, 2012 - Elsevier
We report the implementation of the transnasal image-guided high wavenumber (HW)
Raman spectroscopy to differentiate tumor from normal laryngeal tissue at endoscopy. A …

Machine-learning-assisted spontaneous Raman spectroscopy classification and feature extraction for the diagnosis of human laryngeal cancer

Z Li, Z Li, Q Chen, J Zhang, ME Dunham… - Computers in biology …, 2022 - Elsevier
The early detection of laryngeal cancer significantly increases the survival rates, permits
more conservative larynx sparing treatments, and reduces healthcare costs. A non-invasive …

[HTML][HTML] Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy improves in vivo diagnosis of esophageal squamous cell carcinoma at …

J Wang, K Lin, W Zheng, K Yu Ho, M Teh… - Scientific reports, 2015 - nature.com
This work aims to evaluate clinical value of a fiber-optic Raman spectroscopy technique
developed for in vivo diagnosis of esophageal squamous cell carcinoma (ESCC) during …

Fiber-optic Raman spectroscopy with nature-inspired genetic algorithms enhances real-time in vivo detection and diagnosis of nasopharyngeal carcinoma

P Zuvela, K Lin, C Shu, W Zheng, CM Lim… - Analytical …, 2019 - ACS Publications
Raman spectroscopy is an optical vibrational spectroscopic technique capable of probing
specific biochemical structures and conformation of tissue and cells in biomedical systems …

In vivo, real-time, transnasal, image-guided Raman endoscopy: defining spectral properties in the nasopharynx and larynx

MS Bergholt, K Lin, W Zheng… - Journal of biomedical …, 2012 - spiedigitallibrary.org
We report for the first time the implementation of transnasal, image-guided Raman
endoscopy to directly assess Raman spectral properties of nasopharyngeal and laryngeal …

Deep Learning-Guided Fiberoptic Raman Spectroscopy Enables Real-Time In Vivo Diagnosis and Assessment of Nasopharyngeal Carcinoma and Post-treatment …

C Shu, H Yan, W Zheng, K Lin, A James… - Analytical …, 2021 - ACS Publications
In this work, we develop a deep learning-guided fiberoptic Raman diagnostic platform to
assess its ability of real-time in vivo nasopharyngeal carcinoma (NPC) diagnosis and post …

Fiber-optic Raman spectroscopy for in vivo diagnosis of gastric dysplasia

J Wang, K Lin, W Zheng, KY Ho, M Teh, KG Yeoh… - Faraday …, 2016 - pubs.rsc.org
This study aims to assess the clinical utility of a rapid fiber-optic Raman spectroscopy
technique developed for enhancing in vivo diagnosis of gastric precancer during …