In situ IR was used to precisely prepare high-purity diphenylmethyl 6α-bromopenicillanate 8,
a key intermediate of tazobactam. 8 was obtained when 6α-bromopenicillanic acid 2 reacted …

A short and simple synthesis of 2β-(1, 2, 3-Triazol-1-yl) methyl-2α-methyl-6, 6-
dihydropenicillin-3α-carboxylic acid diphenylmethyl ester (7), on multi-gram scale, is …

Tazobactam is a β-lactamase inhibitor. In this work, a combination of continuous flow and
batch experiments for the synthesis of tazobactam has been developed. The first three steps …

Abstract Tazobactam (9) was synthesized in 8 steps from the readily accessible 6-APA. By
the first use of silver triazole as reactant, the formation of the isomer 7 was avoided and a …

Tazobactam as the third generation antibacterial synergist presented the low toxicity and a
wider antimicrobial spectrum, and dominated in clinical application. Tazobactam sodium …

Herein, we report the development and validation of an HPLC method to analyze
ceftolozane and tazobactam simultaneously in human plasma, human serum, swine serum …

A precise, accurate, sensitive and robust RP‐HPLC method was developed for cefepime
hydrochloride and tazobactam sodium in bulk and pharmaceutical formulation …

A new reversed-phase high-performance liquid chromatography (RP-HPLC) method for the
detection and quantification of tazobactam in serum and haemofiltration fluid is described …

The reactions of class A β-lactamases PC1 and TEM-1 with tazobactam (TZB), a potent
penicillanic sulfone inhibitor for class A β-lactamases, were studied using electrospray …

Despite β-lactamase inhibitors being available for clinical use for nearly 30 years, a paucity
of data exists describing the pharmacokinetic-pharmacodynamic (PK-PD) determinants of …