Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …

Bioactive lipids regulate most physiological processes, from digestion to blood flow and from
hemostasis to labor. Lipid mediators are also involved in multiple pathologies including …

Eicosanoids are cellular metabolites, which shape the immune response, including
inflammatory processes in macrophages. The effects of these lipid mediators on …

Oxylipins are oxygenated metabolites of fatty acids. Eicosanoids are a subset of oxylipins
and include the prostaglandins and leukotrienes, which are potent regulators of host …

Eicosanoids tailor the innate immune response by supporting local inflammation and
exhibiting immunomodulatory properties. Prostaglandin (PG) E2 is the most abundant …

Controlled immune responses to infection and injury involve complex molecular signalling
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …

Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane
phospholipids by phospholipase A2 to ω-3 and ω-6 C20 fatty acids that next are converted …

Macrophages are central to essential physiological processes including the regulation of
innate and adaptive immunity, but they are also central to a number of inflammatory disease …

Inflammation is a response that protects tissues affected by foreign pathogens or physical
trauma. Inflammation is initiated through the carefully orchestrated movement of …

The body is exposed to foreign pathogens every day, but remarkably, most pathogens are
effectively cleared by the innate immune system without the need to invoke the adaptive …