Identifying genetic risk factors for lumbar spine disorders may lead to knowledge regarding
underlying mechanisms and the development of new treatments. We conducted a genome …

Back pain (BP) is a major contributor to disability worldwide, with heritability estimated at 40–
60%. However, less than half of the heritability is explained by common genetic variants …

Back pain is the# 1 cause of years lived with disability worldwide, yet surprisingly little is
known regarding the biology underlying this symptom. We conducted a genome-wide …

Background: Identifying genetic risk factors for spinal disorders may lead to knowledge
regarding underlying molecular mechanisms and the development of new treatments …

Chronic back pain (CBP) is a complex heritable trait and a major cause of disability
worldwide. We developed and validated a genome-wide polygenic risk score (PRS) for CBP …

Objective Low back pain is associated with lumbar disc degeneration, which is mainly due to
genetic predisposition. The objective of this study was to perform a systematic review to …

Study Design.... A case–control genome-wide association study (GWAS) on spondylosis.
Objective.... Leveraging Geisinger's MyCode initiative's multimodal dataset, we aimed to …

Osteoporosis is a serious public health issue, which is mostly characterized by low bone
mineral density (BMD). To search for additional genetic susceptibility loci underlying BMD …

Back pain (BP) is a common condition of major social importance and poorly understood
pathogenesis. Combining data from the UK Biobank and CHARGE consortium cohorts …

Purpose Chronic low back pain (cLBP) is a common health condition worldwide and a
leading cause of disability with an estimated lifetime prevalence of 80–90% in industrialized …