The endocannabinoid system (ECS) is involved in many physiological processes and has
been suggested to play a critical role in the immune response and the central nervous …

Leukocyte function can be modulated through the cannabinoid receptor 2 (CB2R). Using a
cecal ligation and puncture (CLP) model of sepsis, we examined the role of the CB2R during …

The sepsis syndrome represents an improper immune response to pathogens and is
associated with an unacceptably high rate of mortality. Although supportive care is of benefit …

Sepsis is defined as a life-threatening organ dysfunction, caused by a dysregulated host
response to an infection and can progress to septic shock, which represents a major …

Background Sepsis is a major healthcare problem and current estimates suggest that the
incidence of sepsis is approximately 750,000 annually. Sepsis is caused by an inability of …

The endocannabinoid system, with its intricate presence in numerous cells, tissues, and
organs, offers a compelling avenue for therapeutic interventions. Central to this system are …

Central nervous system (CNS) injury, such as stroke or trauma, is known to increase
susceptibility to various infections that adversely affect patient outcomes (CNS injury …

Sepsis is a complex condition that results from a dysregulated immune system in response
to a systemic infection. Current treatments lack effectiveness in reducing the incidence and …

The systemic inflammatory response syndrome can be self‐limited or can progress to severe
sepsis and septic shock. Despite significant advances in the understanding of the molecular …

Abstract The cannabinoid receptor 2 (CB2) is a receptor mainly expressed in immune cells
and believed to be immunosuppressive in infective or inflammatory models. However, its …