Progress in tumor-associated macrophage (TAM)-targeted therapeutics

C Ngambenjawong, HH Gustafson, SH Pun - Advanced drug delivery …, 2017 - Elsevier
As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

[HTML][HTML] Targeting macrophages: a novel treatment strategy in solid tumors

M Liu, L Liu, Y Song, W Li, L Xu - Journal of Translational Medicine, 2022 - Springer
In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …

[HTML][HTML] Targeting tumor-associated macrophages for cancer treatment

M Li, L He, J Zhu, P Zhang, S Liang - Cell & bioscience, 2022 - Springer
Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of
stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like …

[HTML][HTML] Targeting tumor-associated macrophages in cancer immunotherapy

AJ Petty, DH Owen, Y Yang, X Huang - Cancers, 2021 - mdpi.com
Simple Summary Tumor-associated macrophages (TAMs) coinhabit the tumor
microenvironment with cancer, immune, and stromal cells. They undermine the immune …

Targeting tumor-associated macrophages as an antitumor strategy

N Cheng, X Bai, Y Shu, O Ahmad, P Shen - Biochemical pharmacology, 2021 - Elsevier
Tumor-associated macrophages (TAMs) are the most widely infiltrating immune cells in the
tumor microenvironment (TME). Clinically, the number of TAMs is closely correlated with …

[HTML][HTML] Tumor-associated macrophages: A promising target for a cancer immunotherapeutic strategy

SY Zhang, XY Song, Y Li, LL Ye, Q Zhou… - Pharmacological …, 2020 - Elsevier
Macrophages, a type of myeloid immune cell, play essential roles in fighting against
pathogenic invasion and activating T cell-mediated adaptive immune responses. As a major …

[HTML][HTML] Harnessing tumor-associated macrophages as aids for cancer immunotherapy

X Li, R Liu, X Su, Y Pan, X Han, C Shao, Y Shi - Molecular Cancer, 2019 - Springer
Cancer immunotherapies that engage immune cells to fight against tumors are proving to be
powerful weapons in combating cancer and are becoming increasingly utilized in the clinics …

Research trends in pharmacological modulation of tumor‐associated macrophages

N Wang, S Wang, X Wang, Y Zheng… - Clinical and …, 2021 - Wiley Online Library
As one of the most abundant immune cell populations in the tumor microenvironment (TME),
tumor‐associated macrophages (TAMs) play important roles in multiple solid malignancies …

Targeting tumor‐associated macrophages: A potential treatment for solid tumors

Y Chen, H Jin, Y Song, T Huang, J Cao… - Journal of Cellular …, 2021 - Wiley Online Library
Tumor‐associated macrophages (TAMs) in solid tumors exert protumor activities by
releasing cytokines or growth factors into the tumor microenvironment. Increasing studies …

[HTML][HTML] Targeting macrophages in cancer: from bench to bedside

AR Poh, M Ernst - Frontiers in oncology, 2018 - frontiersin.org
Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …