Genetic variants associated with Lp (a) lipoprotein level and coronary disease

R Clarke, JF Peden, JC Hopewell… - … England Journal of …, 2009 - Mass Medical Soc
Background An increased level of Lp (a) lipoprotein has been identified as a risk factor for
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …

Lipoprotein (a): resurrected by genetics

F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …

Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Phenotypic characterization of genetically lowered human lipoprotein (a) levels

CA Emdin, AV Khera, P Natarajan, D Klarin… - Journal of the American …, 2016 - jacc.org
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …

Association of LPA variants with risk of coronary disease and the implications for lipoprotein (a)-lowering therapies: a Mendelian randomization analysis

S Burgess, BA Ference, JR Staley, DF Freitag… - JAMA …, 2018 - jamanetwork.com
Importance Human genetic studies have indicated that plasma lipoprotein (a)(Lp [a]) is
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …

Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …

MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …

Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …

S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …

Genetic evidence that lipoprotein (a) associates with atherosclerotic stenosis rather than venous thrombosis

PR Kamstrup, A Tybjærg-Hansen… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—The aim of the present study was to determine whether lipoprotein (a)[Lp (a)],
considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

LPA Gene, Ethnicity, and Cardiovascular Events

SR Lee, A Prasad, YS Choi, C Xing, P Clopton… - Circulation, 2017 - Am Heart Assoc
Background: The relationship of LPA single nucleotide polymorphisms (SNPs),
apolipoprotein (a) isoforms, and lipoprotein (a)[Lp (a)] levels with major adverse …