Purpose CriticalSorb™, with the principal component Solutol® HS15, is a novel mucosal
drug delivery system demonstrated to improve the bioavailability of selected biotherapeutics …

Purpose CriticalSorb™ is a novel absorption enhancer based on Solutol® HS15, one that
has been found to enhance the nasal transport. It is in clinical trials for nasal delivery of …

Systemic delivery of proteins via the nasal route has to date been limited by their poor
absorption across the nasal mucosa, and the less than optimal tolerability of known …

Present work investigates the potential of absorption enhancers (glucose, EDTA, sodium
cholate, SDS, ethanol and menthol) to open the cellular tight junctions and in doing so …

The inclusion of a chemical permeation enhancer in a dosage form is considered an
effective approach to improve absorption across the nasal mucosa. Herein we evaluated the …

The nasal bioavailability of fluorescein isothiocyanate-dextran (FITC-dextran)(M w= 4300)
encapsulated in non-mucoadhesive and mucoadhesive microspheres in New Zealand …

Absorption enhancement of poorly absorbed hydrophilic compounds from various mucosal
sites by co-administration of a mucolytic agent and a non-ionic surfactant was examined in …

The present article presents a compilation of information regarding various chemical
permeation enhancers useful for transmucosal delivery of macromolecules. In the recent …

We have investigated the effect of sodium salt of capric acid (C10) on major tight junction
proteins such as claudin and occludin, and also examined the involvement of lipid rafts with …

Introduction: Inclusion of absorption-enhancing agents in dosage forms is one approach to
improve the bioavailability of active pharmaceutical ingredients with low membrane …