Aims/hypothesis We investigated whether therapy with the entire daily dose of≥ 1
hypertension medications at bedtime exerts greater reduction in the risk of new-onset …

OBJECTIVE We prospectively investigated in hypertensive patients with type 2 diabetes if
bedtime treatment with≥ 1 hypertension medications exerts better blood pressure control …

This trial investigated whether therapy with the entire daily dose of≥ 1 hypertension
medications at bedtime exerts a greater reduction in the risk of incident chronic kidney …

Generally, hypertensive patients ingest all their blood pressure (BP)-lowering agents in the
morning. However, many published prospective trials have reported clinically meaningful …

Abstract Aims The Hygia Chronotherapy Trial, conducted within the clinical primary care
setting, was designed to test whether bedtime in comparison to usual upon awakening …

Abstract Purpose of Review Current hypertension guidelines do not provide
recommendation on when-to-treat. Herein, we review the current evidence on ingestion-time …

A number of observational studies have found that treated hypertensive patients, even those
with controlled clinic blood pressure (BP), might have poorer prognosis than untreated …

Many published prospective trials have reported clinically meaningful morning-evening,
treatment-time differences in the blood pressure (BP)-lowering efficacy, duration of action …

Combined evidence of published prospective outcome trials and meta-analyses
substantiate elevated asleep blood pressure (BP) and blunted sleep-time relative BP …

Pharmacokinetics of hypertension medications is significantly affected by circadian rhythms
that influence absorption, distribution, metabolism and elimination. Furthermore, their …