Strong evidence that statin medication is linked to type II diabetes raises questions about the
role of cholesterol in insulin secretion and pancreatic β-cell function. Experimentally induced …

OBJECTIVE—Type 2 diabetes is often accompanied by abnormal blood lipid and lipoprotein
levels, but most studies on the link between hyperlipidemia and diabetes have focused on …

Cholesterol is an essential component of cell membranes, and during the past several
years, diabetes researchers have found that membrane cholesterol levels in adipocytes …

Methods: We performed in vitro studies of clonal pancreatic beta-cells (INS-1 832/13) under
diabetic conditions (4mM and 11 mM glucose). Statins were added to cultures 48-72 hours …

The failure of pancreatic β‐cells to supply insulin in quantities sufficient to maintain
euglycemia is a hallmark of type 2 diabetes. Perturbation of β‐cell cholesterol homeostasis …

Pancreatic β-cells, by secreting insulin, play a key role in the control of glucose homeostasis,
and their dysfunction is the basis of diabetes development. The metabolic milieu created by …

Statins are widely used in the treatment of atherosclerosis and hypercholesterolemia, both of
which are comorbidities of obesity. However, the effects statins have on insulin homeostasis …

Insulin secretion from pancreatic β-cells is mediated by the opening of voltage-gated Ca2+
channels (CaV) and exocytosis of insulin dense core vesicles facilitated by the secretory …

Type 2 diabetes (T2D) frequently occurs in the context of a dysregulation of plasma
lipoproteins with an increased triglyceride content in pancreatic beta cells, leading to …

Hypercholesterolemia is common in diabetes. We sought to determine whether cholesterol
(Chol) can exacerbate impaired insulin secretion in islets from a mouse model of mild β-cell …