Proteins belonging to the 'A Disintegrin And Metalloproteinase'(ADAM) family are membrane-
anchored proteases that are able to cleave the extracellular domains of several membrane …

Disintegrin metalloproteases of the ADAM family form a large (at present> 40 members in
mammals) family of multidomain membrane proteins that in their ectodomain combine a …

Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as
highly specific intra-and intermolecular inhibitors of ADAM catalytic activity. The mouse …

A disintegrin and metalloproteinase (ADAM) 10 is a type I transmembrane glycoprotein
responsible for the ectodomain shedding of a range of proteins including the amyloid …

The metalloproteinase and major amyloid precursor protein (APP) α-secretase candidate
ADAM10 is responsible for the shedding of proteins important for brain development, such …

Cleavage of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase)
endopeptidases plays a key role in a wide variety of biological signal transduction and …

Abstract 'A disintegrin and metalloproteases'(ADAMs) are a family of transmembrane
proteins with diverse functions in multicellular organisms. About half of the ADAMs are active …

ADAM (a disintegrin and metalloproteinase) is a family of widely expressed, transmembrane
and secreted proteins of approximately 750 amino acids in length with functions in cell …

A decade ago, a disintegrin and metalloproteinase 10 (ADAM10) was identified as an α‐
secretase and as a key proteinase in the processing of the amyloid precursor protein …

As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has been
identified as the constitutive α-secretase in the process of amyloid-β protein precursor …