Combination and tricombination therapy to destabilize the structural integrity of COVID-19 by some bioactive compounds with antiviral drugs: insights from molecular …

HRA El-Mageed, DA Abdelrheem, SA Ahmed… - Structural …, 2021 - Springer
Abstract Recently, the SARS-CoV-2 (COVID-19) pandemic virus has been spreading
throughout the world. Until now, no certified drugs have been discovered to efficiently inhibit …

Antiviral potential of some novel structural analogs of standard drugs repurposed for the treatment of COVID-19

MF AlAjmi, A Azhar, M Owais, S Rashid… - Journal of …, 2021 - Taylor & Francis
SARS-CoV-2 pandemic has claimed millions of lives across the world. As of June 2020,
there is no FDA approved antiviral therapy to eradicate this dreadful virus. In this study, drug …

Newly identified COVID-19 drug candidates based on computational strategies

P Azerang, M Yazdani, K RayatSanati… - Journal of …, 2022 - World Scientific
The COVID-19 has raised a public health catastrophe in early 2020 worldwide. Despite
several approved vaccines that have repressed the pandemic and decreased the mortality …

Destabilizing the structural integrity of COVID-19 by caulerpin and its derivatives along with some antiviral drugs: an in silico approaches for a combination therapy

SA Ahmed, DA Abdelrheem, HRA El-Mageed… - Structural Chemistry, 2020 - Springer
Abstract Presently, the SARS-CoV-2 (COVID-19) pandemic has been spreading throughout
the world. Some drugs such as lopinavir, simeprevir, hydroxychloroquine, chloroquine, and …

[PDF][PDF] Molecular Docking Assessment of Clinically Approved Antiviral Drugs against Mpro, Spike Glycoprotein and Angiotensin Converting Enzyme-2 Revealed …

TI Adelusi, M Abdul-Hammed, EM Ojo… - Tropical Journal of …, 2021 - researchgate.net
Ever since the novel SARS-CoV-2 coronavirus was identified at Wuhan in China, numerous
researchers have been working on remedies to ameliorate the COVID-19 disease …

[HTML][HTML] Computational studies on potential new anti-Covid-19 agents with a multi-target mode of action

RK Mohapatra, M Azam, PK Mohapatra… - Journal of King Saud …, 2022 - Elsevier
A compound that could inhibit multiple targets associated with SARS-CoV-2 infection would
prove to be a drug of choice against the virus. Human receptor-ACE2, receptor binding …

Peptide-like and small-molecule inhibitors against Covid-19

S Pant, M Singh, V Ravichandiran… - Journal of …, 2021 - Taylor & Francis
Coronavirus disease strain (SARS-CoV-2) was discovered in 2019, and it is spreading very
fast around the world causing the disease Covid-19. Currently, more than 1.6 million …

Expediting the drug discovery for ideal leads against SARS-CoV-2 via molecular docking of repurposed drugs

A Sharma, M Kaur, P Yadav, G Singh… - Journal of Biomolecular …, 2023 - Taylor & Francis
Abstract SARS-CoV-2, the novel coronavirus spreading worldwide urges the need to
repurpose drugs that can quickly enter clinical trials to combat the on-going global …

Molecular docking studies, molecular dynamics and ADME/tox reveal therapeutic potentials of STOCK1N-69160 against papain-like protease of SARS-CoV-2

OO Elekofehinti, O Iwaloye, SS Josiah, AO Lawal… - Molecular Diversity, 2021 - Springer
SARS-CoV-2 is a new strain of Coronavirus that caused the pneumonia outbreak in Wuhan,
China and has spread to over 200 countries of the world. It has received worldwide attention …

Destabilizing the structural integrity of SARS-CoV2 receptor proteins by curcumin along with hydroxychloroquine: an insilco approach for a combination therapy

A Srivastava, D Singh - 2020 - chemrxiv.org
Presently, an emerging disease (COVID-19) has been spreading across the world due to
coronavirus (SARS-CoV2). For treatment of SARS-CoV2 infection, currently …