Propofol is the most important intravenous general anesthetic in current clinical use. It acts
by potentiating GABAA (γ-aminobutyric acid type A) receptors, but where it binds to this …

The GABAA receptor is a target of many general anesthetics. The low affinity of general
anesthetics has complicated the search for the location of anesthetic binding sites. Attention …

Propofol acts as a positive allosteric modulator of γ-aminobutyric acid type A receptors
(GABA A Rs), an interaction necessary for its anesthetic potency in vivo as a general …

γ-Aminobutyric acid type A (GABAA) receptors are an important target for general
anesthetics in the central nervous system. Site-directed mutagenesis techniques have …

Background Propofol produces its major actions via γ-aminobutyric acid type A (GABA (A))
receptors. At low concentrations, propofol enhances agonist-stimulated GABA (A) receptor …

GABA type A receptors (GABA AR), the brain's major inhibitory neurotransmitter receptors,
are the targets for many general anesthetics, including volatile anesthetics, etomidate …

ABSTRACT The intravenous general anesthetic 2, 6-diisopropylphenol (propofol)
potentiates GABAA receptor function, but the precise mechanisms and specificity of this …

GABA A receptors are the major inhibitory neurotransmitter receptors in the brain and are
the target for many clinically important drugs. Among the many modulatory compounds are …

A number of propofol (2, 6-diisopropylphenol) congeners and derivatives were synthesized
and their in vitro capability to affect GABAA receptors determined by the inhibition of the …

The discovery of general anaesthesia, over 150 years ago, revolutionised medicine. The
ability to render a patient unconscious and insensible to pain made modern surgery …