High-gravity technology intensified Knoevenagel condensation-Michael addition polymerization of poly (ethylene glycol)-poly (n-butyl cyanoacrylate) for blood-brain …

X Liu, C Fu, M Wang, J Wang, H Zou, Y Le… - Chinese Journal of …, 2022 - Elsevier
Abstract Poly (ethylene glycol)-poly (n-butyl cyanoacrylate)(PEG-PBCA) is a remarkable
drug delivery carrier for permeating blood-brain barrier. In this work, a novel high-gravity …

Synthesis of a temperature sensitive graft carbon dioxide‐based copolymer and its evaluation as a nano drug carrier

J Xu, H Li, Y Niu - Polymers for Advanced Technologies, 2023 - Wiley Online Library
In this study, a temperature sensitive graft carbon dioxide‐based copolymer, poly (propylene
oxide‐co‐carbon dioxide‐co‐allyl glycidyl ether)‐poly (N‐isopropylacrylamide) …

A new nano hyperbranched β-pinene polymer: Controlled synthesis and nonviral gene delivery

PR Rodrigues, X Wang, Z Li, J Lyu, W Wang… - Colloids and Surfaces B …, 2023 - Elsevier
Recently, an extensive research effort has been directed toward the improvement of nonviral
transfection vectors, such as polymeric materials. The macromolecular structure of polymers …

Delivery of large molecules via poly (butyl cyanoacrylate) nanoparticles into the injured rat brain

Y Lin, Y Pan, Y Shi, X Huang, N Jia, J Jiang - Nanotechnology, 2012 - iopscience.iop.org
Abstract Poly (n-butyl-2-cyanoacrylate)(PBCA) nanoparticles have been successfully
applied to deliver small-molecule drugs to the central nervous system (CNS). However, it is …

Design of amphiphilic PCL-PEG-PCL block copolymers as vehicles of Ginkgolide B and their brain-targeting studies

X Yan, Y Shi, Q Jiang, GF Ping… - Journal of Biomaterials …, 2017 - Taylor & Francis
The amphiphilic PEG-b-PCL block copolymers were synthesized by ring-opening
polymerization. The specific and selective antagonists of platelet activating factor …

Synthesis of a carbon dioxide-based amphiphilic block copolymer and its evaluation as a nanodrug carrier

H Li, L Sui, Y Niu - Journal of materials science, 2018 - Springer
A series of novel amphiphilic block copolymers poly (propylene carbonate)-block-mono-
methoxy poly (ethylene oxide)(PPC-b-MPEG) composed of hydrophobic PPC segments and …

Amphiphilic graft copolymer based on poly (styrene-co-maleic anhydride) with low molecular weight polyethylenimine for efficient gene delivery

X Duan, J Xiao, Q Yin, Z Zhang, S Mao… - International journal of …, 2012 - Taylor & Francis
Background and methods A new amphiphilic comb-shaped copolymer (SP) was
synthesized by conjugating poly (styrene-co-maleic anhydride) with low molecular weight …

Controllable polymerization of n-butyl cyanoacrylate using a high-gravity rotating packed bed

X Liu, J Jin, Y Chen, B Lu, Q Sun, J Wang… - Chemical Engineering …, 2020 - Elsevier
Abstract Poly (n-butyl cyanoacrylate)(PBCA) nanoparticles are widely used as
biocompatible and bio-erosive materials in a range of biomedical applications, especially for …

A one-pot method to enhance dissolution rate of low solubility drug molecules using dispersion polymerization in supercritical carbon dioxide

A Galia, O Scialdone, G Filardo, T Spanò - International journal of …, 2009 - Elsevier
The surfactant assisted polymerization of 1-vinyl-2-pyrrolidone in supercritical carbon
dioxide in the presence of Piroxicam, selected as a model of a low aqueous solubility drug …

Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

W Ke, K Shao, R Huang, L Han, Y Liu, J Li, Y Kuang… - Biomaterials, 2009 - Elsevier
Angiopep targeting to the low-density lipoprotein receptor-related protein-1 (LRP1) was
identified to exhibit high transcytosis capacity and parenchymal accumulation. In this study, it …