The regulation and function of Class III PI3Ks: novel roles for Vps34
JM Backer - Biochemical Journal, 2008 - portlandpress.com
The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …
hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells
Y Yan, RJ Flinn, H Wu, RS Schnur… - Biochemical …, 2009 - portlandpress.com
The mammalian Class III PI3K (phosphoinositide 3-kinase), hVps34 [mammalian Vps
(vacuolar protein sorting) 34 homologue], is an important regulator of vesicular trafficking …
(vacuolar protein sorting) 34 homologue], is an important regulator of vesicular trafficking …
hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling
T Nobukuni, SC Kozma, G Thomas - Current opinion in cell biology, 2007 - Elsevier
Recent studies have shown that the nutrient input to the mTOR Complex1/S6K1 signaling
pathway is mediated by class 3 PI3K or hVps34, the oldest member of the PI3K family …
pathway is mediated by class 3 PI3K or hVps34, the oldest member of the PI3K family …
Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae
A Kihara, T Noda, N Ishihara, Y Ohsumi - The Journal of cell biology, 2001 - rupress.org
Vps30p/Apg6p is required for both autophagy and sorting of carboxypeptidase Y (CPY).
Although Vps30p is known to interact with Apg14p, its precise role remains unclear. We …
Although Vps30p is known to interact with Apg14p, its precise role remains unclear. We …
PI (5) P regulates autophagosome biogenesis
M Vicinanza, VI Korolchuk, A Ashkenazi, C Puri… - Molecular cell, 2015 - cell.com
Summary Phosphatidylinositol 3-phosphate (PI (3) P), the product of class III PI3K VPS34,
recruits specific autophagic effectors, like WIPI2, during the initial steps of autophagosome …
recruits specific autophagic effectors, like WIPI2, during the initial steps of autophagosome …
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
JM Backer - Biochemical Journal, 2016 - portlandpress.com
The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …
Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function
N Jaber, WX Zong - Annals of the New York Academy of …, 2013 - Wiley Online Library
Mammalian phosphatidylinositol (PI) 3‐kinases are a family of proteins that share the ability
to phosphorylate phosphoinositides at the 3 position of the inositol ring. By doing so, these …
to phosphorylate phosphoinositides at the 3 position of the inositol ring. By doing so, these …
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis
K Devereaux, C Dall'Armi, A Alcazar-Roman… - PloS one, 2013 - journals.plos.org
Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III
phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) …
phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) …
A membrane‐associated complex containing the Vps15 protein kinase and the Vps34 PI 3‐kinase is essential for protein sorting to the yeast lysosome‐like vacuole.
JH Stack, PK Herman, PV Schu, SD Emr - The EMBO journal, 1993 - embopress.org
The Vps15 protein kinase and the Vps34 phosphatidylinositol 3‐kinase (PI 3‐kinase) are
required for the sorting of soluble hydrolases to the yeast vacuole. Over‐production of …
required for the sorting of soluble hydrolases to the yeast vacuole. Over‐production of …
Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology
K Takegawa, DB DeWald, SD Emr - Journal of cell science, 1995 - journals.biologists.com
We have cloned the gene, vps34+, from the fission yeast Schizosaccharomyces pombe
which encodes an 801 amino acid protein with phosphatidylinositol 3-kinase activity. The S …
which encodes an 801 amino acid protein with phosphatidylinositol 3-kinase activity. The S …