The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

The mammalian Class III PI3K (phosphoinositide 3-kinase), hVps34 [mammalian Vps
(vacuolar protein sorting) 34 homologue], is an important regulator of vesicular trafficking …

Vps30p/Apg6p is required for both autophagy and sorting of carboxypeptidase Y (CPY).
Although Vps30p is known to interact with Apg14p, its precise role remains unclear. We …

Summary Phosphatidylinositol 3-phosphate (PI (3) P), the product of class III PI3K VPS34,
recruits specific autophagic effectors, like WIPI2, during the initial steps of autophagosome …

Mammalian phosphatidylinositol (PI) 3‐kinases are a family of proteins that share the ability
to phosphorylate phosphoinositides at the 3 position of the inositol ring. By doing so, these …

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …

Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III
phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) …

The Vps15 protein kinase and the Vps34 phosphatidylinositol 3‐kinase (PI 3‐kinase) are
required for the sorting of soluble hydrolases to the yeast vacuole. Over‐production of …

We have cloned the gene, vps34+, from the fission yeast Schizosaccharomyces pombe
which encodes an 801 amino acid protein with phosphatidylinositol 3-kinase activity. The S …

A critical regulator of autophagy is the Class III PI3K Vps34 (also called PIK3C3). Although
Vps34 is known to play an essential role in autophagy in yeast, its role in mammals remains …