[HTML][HTML] Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein
LT Wang, LS Pereira, PK Kiyuka, A Schön… - PLoS …, 2021 - journals.plos.org
Combinations of monoclonal antibodies (mAbs) against different epitopes on the same
antigen synergistically neutralize many viruses. However, there are limited studies …
antigen synergistically neutralize many viruses. However, there are limited studies …
Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection
Antibodies against the central repeat of the Plasmodium falciparum (Pf) circumsporozoite
protein (CSP) inhibit parasite activity and correlate with protection from malaria. However …
protein (CSP) inhibit parasite activity and correlate with protection from malaria. However …
[HTML][HTML] In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)
MC Livingstone, AA Bitzer, A Giri, K Luo… - Scientific reports, 2021 - nature.com
Plasmodium falciparum malaria contributes to a significant global disease burden.
Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime …
Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime …
[HTML][HTML] A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
Potent and durable vaccine responses will be required for control of malaria caused by
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZs) has been shown
to be protective against malaria, but the features of the antibody response induced by this …
to be protective against malaria, but the features of the antibody response induced by this …
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Abstract Development of a highly effective vaccine or antibodies for the prevention and
ultimately elimination of malaria is urgently needed. Here we report the isolation of a number …
ultimately elimination of malaria is urgently needed. Here we report the isolation of a number …
Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile …
MD Porter, J Nicki, CD Pool, M DeBot… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
Circumsporozoite protein (CSP) of Plasmodium falciparum is a protective human malaria
vaccine candidate. There is an urgent need for models that can rapidly down-select novel …
vaccine candidate. There is an urgent need for models that can rapidly down-select novel …
How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein
I Wahl, H Wardemann - Journal of experimental medicine, 2022 - rupress.org
The induction of protective humoral immune responses against sporozoite surface proteins
of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a …
of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a …
[HTML][HTML] Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein
Lasting protection has long been a goal for malaria vaccines. The major surface antigen on
Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an …
Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an …
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies
OE Oludada, G Costa, C Burn Aschner… - EMBO Molecular …, 2023 - embopress.org
Human monoclonal antibodies (mAbs) against the central repeat and junction domain of
Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to …
Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to …
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