Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

Down syndrome (DS), also known as trisomy 21, is the most common genetic cause of
intellectual disability. It is also a model human disease for exploring consequences of gene …

Down syndrome (DS) is associated with neurological complications, including cognitive
deficits that lead to impairment in intellectual functioning. Increased GABA-mediated …

Excess inhibition in the brain of individuals carrying an extra copy of chromosome 21 could
be responsible for cognitive deficits observed throughout their lives. A change in the …

Cognitive impairment in Down syndrome (DS) involves the hippocampus. In the Ts65Dn
mouse model of DS, deficits in hippocampus-dependent learning and synaptic plasticity …

Cognitive impairment in Down syndrome (DS) is characterized by deficient learning and
memory. Mouse genetic models of DS exhibit impaired cognition in hippocampally mediated …

An imbalance between inhibitory and excitatory neurotransmission has been proposed to
contribute to altered brain function in individuals with Down syndrome (DS). Gamma …

Down syndrome (DS) is caused by the overexpression of genes on triplicated regions of
human chromosome 21 (Hsa21). While the resulting physiological and behavioral …

Down syndrome, the most common genetic cause of intellectual disability, is associated with
brain disorders due to chromosome 21 gene overdosage. Molecular and cellular …

Down Syndrome (DS) is the most common genetic cause of intellectual disability in which
delays and impairments in brain development and function lead to neurological and …