Despite the fact that genes and the environment are known to play a central role in islet
function, our knowledge of how these parameters interact to modulate insulin secretory …

In insulin-resistant status such as obesity, failure of pancreatic islets to increase insulin
secretion leads to diabetes. We sought to screen for the islet genes that facilitate islet …

Human islet research is providing new insights into human islet biology and diabetes, using
islets isolated at multiple US centers from donors with varying characteristics. This creates …

One complication to comparing β-cell function among islet preparations, whether from
genetically identical or diverse animals or human organ donors, is the number of islets …

Consumption of a glucose diet for 4 d markedly elevates plasma insulin concentrations in
adrenalectomized ob/ob mice. The present study examined regulation of insulin secretion …

Preliminary experiments about the suitability of different commonly used culture media in our
laboratory indicated, that prolonged exposure to high glucose concentrations during low …

Islet protein profiling is defined as generation of extended protein expression data sets from
islets or islet cells. Islets from rodent control and animal models of type 1 and type 2 diabetes …

The high fat–fed mouse is an experimental model for studies of islet dysfunction as a
mechanism for glucose intolerance and for evaluation of therapeutic targets. This model is …

Maternal overnutrition is associated with increased susceptibility to type 2 diabetes in the
offspring. Rodent models have shown that maternal overnutrition influences islet function in …

Islet β-cells express both insulin receptors and insulin-signaling proteins. Recent evidence
from rodents in vivo and from islets isolated from rodents or humans suggests that the insulin …