[HTML][HTML] MLL-rearranged leukemias—an update on science and clinical approaches
AC Winters, KM Bernt - Frontiers in pediatrics, 2017 - frontiersin.org
The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia
T Chowdhury, HJM Brady - Blood Cells, Molecules, and Diseases, 2008 - Elsevier
Translocations involving the Mixed Lineage Leukemia (MLL) gene at 11q23 are found in
both acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML), but have …
both acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML), but have …
MLL-Rearranged Acute Lymphoblastic Leukemia
F El Chaer, M Keng, KK Ballen - Current Hematologic Malignancy Reports, 2020 - Springer
Abstract Purpose of Review Rearrangements of the histone lysine [K]-MethylTransferase 2A
gene (KMT2A) gene on chromosome 11q23, formerly known as the mixed-lineage leukemia …
gene (KMT2A) gene on chromosome 11q23, formerly known as the mixed-lineage leukemia …
MLL fusions: pathways to leukemia
Human leukemia with chromosomal band 11q23 aberrations that disrupt the MLL/HRX/ALL-
1 gene portends poor prognosis1-13. MLL associated leukemias account for the majority of …
1 gene portends poor prognosis1-13. MLL associated leukemias account for the majority of …
[HTML][HTML] Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions
Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL
or KMT2A) are highly prevalent in pediatric oncology. The poor survival rate and lack of an …
or KMT2A) are highly prevalent in pediatric oncology. The poor survival rate and lack of an …
The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia
BV Balgobind, CM Zwaan, R Pieters… - Leukemia, 2011 - nature.com
Translocations involving the mixed-lineage leukemia (MLL) gene, localized at 11q23,
comprise 15 to 20% of all pediatric acute myeloid leukemia (AML) cases. This review …
comprise 15 to 20% of all pediatric acute myeloid leukemia (AML) cases. This review …
New insights to the MLL recombinome of acute leukemias
C Meyer, E Kowarz, J Hofmann, A Renneville, J Zuna… - Leukemia, 2009 - nature.com
Chromosomal rearrangements of the human MLL gene are associated with high-risk
pediatric, adult and therapy-associated acute leukemias. These patients need to be …
pediatric, adult and therapy-associated acute leukemias. These patients need to be …
[HTML][HTML] The MLL recombinome of acute leukemias in 2017
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant,
pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained …
pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained …
[HTML][HTML] The MLL recombinome of acute leukemias in 2013
C Meyer, J Hofmann, T Burmeister, D Gröger, TS Park… - Leukemia, 2013 - nature.com
Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are
associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We …
associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We …
Mechanisms of leukemogenesis by MLL fusion proteins
R Marschalek - British journal of haematology, 2011 - Wiley Online Library
Infant acute leukaemia is characterised by specific genetic rearrangements and a rapid
onset of disease shortly after birth. The vast majority of these cases bear rearranged MLL …
onset of disease shortly after birth. The vast majority of these cases bear rearranged MLL …