Background: Mitochondria have emerged as a major target for anticancer therapy because
of their critical role in cancer cell survival. Our preliminary works have suggested that …

Lung cancer is a common malignant disease with a high incidence rate worldwide, posing a
great threat to human health. To date, only a small number of studies have assessed the …

Anthracyclines such as doxorubicin (Dox) are widely used to treat a variety of adult and
childhood cancers, however, a major limitation to many of these compounds is their …

Lung cancer is one of the leading causes of cancer death. Non-small-cell lung cancer
(NSCLC) accounts for the majority of lung cancer diagnoses. Dihydrotanshinone (DHT) is a …

Abstract Deoxyarbutin (DeoxyArbutin, dA), a natural compound widely used in skin lighting,
displayed selectively cytotoxicity in vitro. In the study, we found that dA significantly inhibited …

Erastin, a classical inducer of non‑apoptotic cell death, exerts cytotoxicity in several types of
cancer cells, including gastric cancer cells, by depleting glutathione, which is a primary …

Tetrandrine, a bis-benzylisoquinoline alkaloid isolated from the dried root of Hang-Fang-Chi
(Stephania tetrandra S. Moore), has been reported to possess anti-cancer effects on many …

The identification of large numbers of genetic mutations in immature myeloid cells has made
it difficult to identify specific targets for acute myeloid leukemia (AML) therapy. Although …

Esophageal cancer is of high prevalence and poor prognosis. Hesperetin has been reported
to exert antitumor ability by inducing apoptosis in many cancers in vitro and in vivo without …

The main mechanistic function of most chemotherapeutic drugs is mediated by inducing
mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to …