Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

Kindlins and talins are integrin-binding proteins that are critically involved in integrin
activation, an essential process for many fundamental cellular activities including cell-matrix …

Abstract Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors
are important for development, immune response, hemostasis and wound healing. Integrins …

Integrins are the major family of adhesion molecules that mediate cell adhesion to the
extracellular matrix. They are essential for embryonic development and influence numerous …

Integrins require an activation step prior to ligand binding and signaling. How talin and
kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we …

Talin-induced integrin binding to extracellular matrix ligands (integrin activation) is the key
step to trigger many fundamental cellular processes including cell adhesion, cell migration …

Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Talins are cytoplasmic adapter proteins essential for integrin‐mediated cell adhesion to the
extracellular matrix. Talins control the activation state of integrins, link integrins to …

Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix
adhesion. Although all integrins can undergo activation (affinity change for ligands), the …