The role of mitochondria in NLRP3 inflammasome activation
Q Liu, D Zhang, D Hu, X Zhou, Y Zhou - Molecular immunology, 2018 - Elsevier
The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …
Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?
Background The NLRP3 inflammasome is a sensor of specific pathogen, host and
environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves …
environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves …
Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
Inflammasomes are multimeric protein complexes that induce the cleavage and release of
bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse …
bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse …
Initiation and perpetuation of NLRP 3 inflammasome activation and assembly
EI Elliott, FS Sutterwala - Immunological reviews, 2015 - Wiley Online Library
The NLRP 3 (NOD‐like receptor family, pyrin domain containing 3) inflammasome is a
multiprotein complex that orchestrates innate immune responses to infection and cell stress …
multiprotein complex that orchestrates innate immune responses to infection and cell stress …
Mitochondrial apoptosis is dispensable for NLRP 3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
A current paradigm proposes that mitochondrial damage is a critical determinant of NLRP 3
inflammasome activation. Here, we genetically assess whether mitochondrial signalling …
inflammasome activation. Here, we genetically assess whether mitochondrial signalling …
Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome
T Horng - Trends in immunology, 2014 - cell.com
The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to
maturation of interleukin-1β (IL-1β) and IL-18 and induction of proinflammatory cell death in …
maturation of interleukin-1β (IL-1β) and IL-18 and induction of proinflammatory cell death in …
Cutting edge: mitochondrial assembly of the NLRP3 inflammasome complex is initiated at priming
EI Elliott, AN Miller, B Banoth, SS Iyer… - The Journal of …, 2018 - journals.aai.org
The NLRP3 inflammasome is activated in response to microbial and danger signals,
resulting in caspase-1–dependent secretion of the proinflammatory cytokines IL-1β and IL …
resulting in caspase-1–dependent secretion of the proinflammatory cytokines IL-1β and IL …
Defective mitochondrial fission augments NLRP3 inflammasome activation
Despite the fact that deregulated NLRP3 inflammasome activation contributes to the
pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by …
pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by …
Mitochondria: Sovereign of inflammation?
J Tschopp - European journal of immunology, 2011 - Wiley Online Library
NLRP3 inflammasome‐dependent inflammatory responses are triggered by a variety of
signals of host danger, including infection, tissue damage and metabolic dysregulation. How …
signals of host danger, including infection, tissue damage and metabolic dysregulation. How …
The roles of endoplasmic reticulum in NLRP3 inflammasome activation
Y Zhou, Z Tong, S Jiang, W Zheng, J Zhao, X Zhou - Cells, 2020 - mdpi.com
The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …