Treatment and prevention of urinary tract infection with orally active FimH inhibitors
CK Cusumano, JS Pinkner, Z Han, SE Greene… - Science translational …, 2011 - science.org
Chronic and recurrent urinary tract infections pose a serious medical problem because there
are few effective treatment options. Patients with chronic urinary tract infections are …
are few effective treatment options. Patients with chronic urinary tract infections are …
FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation
T Klein, D Abgottspon, M Wittwer… - Journal of medicinal …, 2010 - ACS Publications
Urinary tract infection (UTI) by uropathogenic Escherichia coli (UPEC) is one of the most
common infections, particularly affecting women. The interaction of FimH, a lectin located at …
common infections, particularly affecting women. The interaction of FimH, a lectin located at …
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile
S Kleeb, L Pang, K Mayer, D Eris, A Sigl, RC Preston… - 2015 - ACS Publications
Urinary tract infections (UTIs), predominantly caused by uropathogenic Escherichia coli
(UPEC), belong to the most prevalent infectious diseases worldwide. The attachment of …
(UPEC), belong to the most prevalent infectious diseases worldwide. The attachment of …
FimH Antagonists: Structure–Activity and Structure–Property Relationships for Biphenyl α‐D‐Mannopyranosides
L Pang, S Kleeb, K Lemme, S Rabbani… - …, 2012 - Wiley Online Library
Urinary tract infections (UTIs) are caused primarily by uropathogenic Escherichia coli
(UPEC), which encode filamentous surface‐adhesive organelles called type 1 pili. FimH is …
(UPEC), which encode filamentous surface‐adhesive organelles called type 1 pili. FimH is …
Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease
LK Mydock-McGrane, TJ Hannan… - Expert opinion on drug …, 2017 - Taylor & Francis
ABSTRACT Introduction: The bacterial adhesin FimH is a virulence factor and an attractive
therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type …
therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type …
Antivirulence isoquinolone mannosides: optimization of the biaryl aglycone for FimH lectin binding affinity and efficacy in the treatment of chronic UTI
Uropathogenic E. coli (UPEC) employ the mannose‐binding adhesin FimH to colonize the
bladder epithelium during urinary tract infection (UTI). Previously reported FimH antagonists …
bladder epithelium during urinary tract infection (UTI). Previously reported FimH antagonists …
Antiadhesion Therapy for Urinary Tract Infections A Balanced PK/PD Profile Proved To Be Key for Success
X Jiang, D Abgottspon, S Kleeb… - Journal of medicinal …, 2012 - ACS Publications
The initial step for the successful establishment of urinary tract infections (UTIs),
predominantly caused by uropathogenic Escherichia coli, is the adhesion of bacteria to …
predominantly caused by uropathogenic Escherichia coli, is the adhesion of bacteria to …
Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists
O Schwardt, S Rabbani, M Hartmann… - Bioorganic & medicinal …, 2011 - Elsevier
Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the
most prevalent infectious diseases. Particularly affected are women, who have a 40–50 …
most prevalent infectious diseases. Particularly affected are women, who have a 40–50 …
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice
PS Guiton, CK Cusumano, KA Kline… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial
urinary tract infections (UTIs) and pose significant clinical challenges. These infections are …
urinary tract infections (UTIs) and pose significant clinical challenges. These infections are …
FimH and anti-adhesive therapeutics: a disarming strategy against uropathogens
Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that
allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic …
allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic …
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