Combination drugs are an important class of US FDA approved pharmaceuticals. These
drugs have been on a continuous growth trajectory since the first combination drugs were …

Experience in clinical practice and research in systems pharmacology suggested the
limitations of the current one-drug-one-target paradigm in new drug discovery. Single-target …

In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

Rapid advances in pharmaceutical sciences have brought ever-increasing interests in
combined therapies for better clinical efficacy and safety, especially in cases of complicated …

Combinatorial therapies have been recently proposed to improve the efficacy of anticancer
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …

Abstract DrugCentral (http://drugcentral. org) is an open-access online drug compendium.
DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and …

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was
very well received. Comprehensive Medicinal Chemistry II is much more than a simple …

Motivation: Drug combinations are a promising strategy for combating complex diseases by
improving the efficacy and reducing corresponding side effects. Currently, a widely studied …

New drugs introduced to the market every year represent privileged structures for particular
biological targets. These new chemical entities (NCEs) provide insight into molecular …

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and
forward-looking critical analysis and summary of recent developments, emerging trends, and …