Adipocytes are important but underappreciated components of bone marrow
microenvironment, and their numbers greatly increase with age, obesity, and associated …

The bone marrow is a favored site for a number of cancers, including the hematological
malignancy multiple myeloma, and metastasis of breast and prostate cancer. This …

Adipocytes are a significant component of the bone marrow microenvironment. Although
bone marrow adipocytes were first identified more than 100 years ago, it is only in recent …

Increased bone marrow adiposity is a common feature of advanced age, obesity and
associated metabolic pathologies. Augmented numbers of marrow adipocytes positively …

Simple Summary This review discusses the important newly-established roles for bone
marrow adipose tissue in cancer progression and highlights the research demonstrating …

The high incidences of bone metastasis in patients with breast cancer, prostate cancer and
lung cancer still remains a puzzling issue. The “seeds and soil” hypothesis suggested that …

The relationship between fat, bone and systemic metabolism is a growing area of scientific
interest. Marrow adipose tissue is a well-recognized component of the bone marrow milieu …

Purpose Bone marrow adipocytes (BMAs) are the most plentiful cells in the bone marrow
and function as an endocrine organ by producing fatty acids, cytokines, and adipokines …

Bone metastasis occurs frequently in cancer patients. Conventional therapies have limited
therapeutic outcomes, and thus, exploring the mechanisms of cancer progression in bone …

Bone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and
serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by …