Mutation-independent proteomic signatures of pathological progression in murine models of Duchenne muscular dystrophy

TLE van Westering, HJ Johansson, B Hanson… - Molecular & Cellular …, 2020 - ASBMB
The absence of the dystrophin protein in Duchenne muscular dystrophy (DMD) results in
myofiber fragility and a plethora of downstream secondary pathologies. Although a variety of …

Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy

T Fröhlich, E Kemter, F Flenkenthaler, N Klymiuk… - Scientific reports, 2016 - nature.com
Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and
characterized by massive structural and functional changes of skeletal muscle tissue …

Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy

DW Van Pelt, YA Kharaz, DC Sarver… - Connective Tissue …, 2021 - Taylor & Francis
ABSTRACT Purpose/Aim Duchenne muscular dystrophy (DMD) is a progressive
neuromuscular disease characterized by extensive muscle weakness. Patients with DMD …

Mass spectrometry‐based protein analysis to unravel the tissue pathophysiology in Duchenne muscular dystrophy

SJ Carr, RP Zahedi, H Lochmüller… - PROTEOMICS–Clinical …, 2018 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is a genetic muscle wasting condition with limited
treatment options available and is caused by the lack of dystrophin. However …

[PDF][PDF] Gene expression profiling of Duchenne muscular dystrophy reveals characteristics along disease progression

LJ Tian, JH Cao, XQ Deng, CL Zhang, T Qian… - Genet. Mol …, 2014 - geneticsmr.com
Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy with
no cure currently available. In this study, using two microarray data sets obtained from the …

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

Y Hathout, E Brody, PR Clemens… - Proceedings of the …, 2015 - National Acad Sciences
Serum biomarkers in Duchenne muscular dystrophy (DMD) may provide deeper insights
into disease pathogenesis, suggest new therapeutic approaches, serve as acute read-outs …

Gene expression profiling of Duchenne muscular dystrophy skeletal muscle

JN Haslett, D Sanoudou, AT Kho, M Han, RR Bennett… - Neurogenetics, 2003 - Springer
The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin
gene, leading to absence of the corresponding protein, disruption of the dystrophin …

Proteome Profiling of the Dystrophic mdx Mice Diaphragm

O Mucha, M Myszka, P Podkalicka, B Świderska… - Biomolecules, 2023 - mdpi.com
Mdx mice with a spontaneous mutation in exon 23 of the Dmd gene represent the most
common model to investigate the pathophysiology of Duchenne muscular dystrophy (DMD) …

Simultaneous Pathoproteomic Evaluation of the Dystrophin-Glycoprotein Complex and Secondary Changes in the mdx-4cv Mouse Model of Duchenne Muscular …

S Murphy, M Henry, P Meleady, M Zweyer… - Biology, 2015 - mdpi.com
In skeletal muscle, the dystrophin-glycoprotein complex forms a membrane-associated
assembly of relatively low abundance, making its detailed proteomic characterization in …

[HTML][HTML] The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophy

JCW Hildyard, DO Riddell, RCM Harron… - Wellcome Open …, 2022 - ncbi.nlm.nih.gov
Background: Animal models of Duchenne muscular dystrophy (DMD) are essential to study
disease progression and assess efficacy of therapeutic intervention, however dystrophic …