Cancer has become one of the leading causes of morbidity and mortality worldwide. This
disease is classified broadly by tissue, organ, and system; different cancer types and …

A new era of medical technology in cancer treatment is a directly specific modification of
gene expression in tumor cells by nucleic acid delivery. Currently, the main challenge to …

Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

With the development of nanotechnology, various types of polymer-based drug delivery
systems have been designed for biomedical applications. Polymer-based drug delivery …

Polyethyleneimine (PEI) is a cationic polymer used as a gold standard in non-viral gene
delivery. The extraordinary cationic charge and buffering capacity of the PEI has been …

Since the first published examination of poly (ethylenimine)(PEI) as a gene delivery vehicle,
there has been a flurry of research aimed at this polycation and its role in gene therapy …

Gene therapy using recombinant DNA or gene silencing using siRNA have become a
prominent area of research in cancer therapy. However, their use in clinical applications is …

The polycation polyethylenimine (PEI) has recently been widely employed for the design of
DNA delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

Polyethylenimine (PEI) is a cationic polymer with high transfection efficiency as non‐viral
gene delivery agent that exhibits promising features for gene therapy applications due to its …

While an effective non-viral gene carrier, 25kDa branched polyethylenimine (PEI) is
cytotoxic, and decreasing its toxicity while maintaining its functionality is vital. Conjugation of …