Cadmium‐induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH‐SY5Y cells

Z Li, Y Shi, Y Wang, H Qi, H Chen… - Environmental …, 2023 - Wiley Online Library
Cadmium (Cd) is a hypertoxic heavy metal that may be exposed to environmental pollutants
by humans and animals. It can lead to cognitive disfunction, and is linked to …

[HTML][HTML] Cadmium exposure induces pyroptosis of TM4 cells through oxidative stress damage and inflammasome activation

J Zhou, Y Zhang, L Zeng, X Wang, W Xiang… - … and Environmental Safety, 2024 - Elsevier
Cadmium (Cd) is a harmful metal that seriously affects the male reproductive system, but the
mechanism of how Cd exposure damages Sertoli cells is not fully understood. This study …

NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis

D Wang, Y Wu, S Sun, P Zhao, X Zhou, C Liang… - Science of The Total …, 2023 - Elsevier
Cadmium (Cd), a toxic heavy metal, exerts deleterious effects on neuronal survival and
cognitive function. NOD-like receptor 3 (NLRP3) inflammasome-dependent pyroptosis has …

Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

L Chen, L Liu, S Huang - Free Radical Biology and Medicine, 2008 - Elsevier
Cadmium (Cd), a highly toxic environmental pollutant, induces neurodegenerative diseases.
Recently we have demonstrated that Cd may induce neuronal apoptosis in part through …

Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse …

S Wang, X Ren, X Hu, L Zhou, C Zhang… - Toxicology and applied …, 2019 - Elsevier
Cadmium (Cd) is a heavy metal that widely exists in the environment and industry, and
which causes serious damages to reproductive system. Recent studies have reported that …

MAPK and mTOR pathways are involved in cadmium‐induced neuronal apoptosis

L Chen, L Liu, Y Luo, S Huang - Journal of neurochemistry, 2008 - Wiley Online Library
Cadmium (Cd) may be accumulated in human body through long‐term exposure to Cd‐
polluted environment, resulting in neurodegeneration and other diseases. To study the …

Cadmium inhibits neural stem/progenitor cells proliferation via MitoROS‐dependent AKT/GSK‐3β/β‐catenin signaling pathway

H Luo, B Song, G Xiong, B Zhang, Z Zuo… - Journal of Applied …, 2021 - Wiley Online Library
Cadmium (Cd) is a toxic heavy metal widely found in the environment. Cd is also a potential
neurotoxicant, and its exposure is associated with impairment of cognitive function …

ROS‐mediated PERK‐CHOP pathway plays an important role in cadmium‐induced HepG2 cells apoptosis

C Zhaohui, T Cifei, H Di, Z Weijia… - Environmental …, 2023 - Wiley Online Library
Cadmium (Cd) is a common heavy metal that is highly toxic to the liver, however, the exact
mechanism underlying this damage accompanied by apoptosis has not been thoroughly …

Transcription factor E3 protects against cadmium-induced apoptosis by maintaining the lysosomal-mitochondrial axis but not autophagic flux in Neuro-2a cells

H Pi, M Li, J Xie, Z Yang, Y Xi, Z Yu, Z Zhou - Toxicology Letters, 2018 - Elsevier
Cadmium (Cd), is a well-known environmental and occupational hazard with a potent
neurotoxic action. However, the mechanism underlying cadmium-induced neurotoxicity …

Lead exposure induces neurodysfunction through caspase-1-mediated neuronal pyroptosis

D Peng, L Wang, Y Fang, L Lu, Z Li, S Jiang… - Environmental …, 2024 - Elsevier
Chronic lead (Pb) exposure causes neurodysfunction and contributes to the development of
neurodegenerative disease. However, the mechanism of Pb-induced neurological …