In recent decades, heparin, as the most important anticoagulant drug, has been widely used
in clinical settings to prevent and treat thrombosis in a variety of diseases. However, with in …

Heparin has been widely used as an anticoagulant for more than 80 years. However, there
is now considerable evidence that heparin also possesses anti‐inflammatory activity, both …

Heparin is a life-saving drug, which belongs to few clinically used drugs without defined
molecular structures in modern medicine. Heparin is the mostly negatively charged …

The key reason behind the success of heparin in thrombosis and beyond is its
polypharmacological sites of action for the prevention and treatment of multifactorial …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Heparins represent one of the most frequently used pharmacotherapeutics. Discovered
around 1926, routine clinical anticoagulant use of heparin was initiated only after the …

Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100
years have passed since the initial discovery of this complex substance and, during this …

Heparin is the earliest and most widely used anticoagulant and antithrombotic drug that is
still used in a variety of clinical indications. Since it was discovered in 1916, after more than …

Heparin was the first anticoagulant agent to be discovered and isolated for medical use, and
is one of the oldest drugs still to be in widespread clinical use. Indeed, heparin remains on …

Heparin is a glycosaminoglycan with anticoagulant properties and antiinflammatory effects.
The discovery of heparin approaches its 100th year and its antiinflammatory properties still …