Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …

The ubiquitin-proteasome system (UPS) is the major machinery mediating specific protein
turnover in eukaryotic cells. By ubiquitylating unwanted, damaged, or harmful proteins and …

PROteolysis TArgeting Chimeras (PROTACs) are of significant current interest for the
development of probe molecules and drug leads. However, they suffer from certain …

Selective degradation of proteins by proteolysis targeting chimeras (PROTACs) offers a
promising potential alternative to protein inhibition for therapeutic intervention. Current …

Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we
report a previously understudied benefit of small molecule proteolysis-targeting chimeras …

Advancement in our knowledge of deubiquitinases (DUBs) and their biological functions
requires biochemical tools permitting interrogation of DUB activities under physiologically …

Proteolysis Targeting Chimeras (PROTACs) are attractive therapeutic modalities for
degrading disease-causing proteins. While many PROTACs have been developed for …

Protein conformation and function are often inextricably linked, such that the states a protein
adopts define its enzymatic activity or its affinity for various partners. Here we combine …

Proteolysis targeting chimera (PROTAC) technology is a chemical protein knockdown
approach that degrades protein by hijacking the cellular ubiquitin-proteasome system to …

Ubiquitination is a key posttranslational modification, which affects numerous biological
processes and is reversed by a class of enzymes known as deubiquitinases (DUBs). This …