Cryo-EM structure of the insect olfactory receptor Orco
The olfactory system must recognize and discriminate amongst an enormous variety of
chemicals in the environment. To contend with such diversity, insects have evolved a family …
chemicals in the environment. To contend with such diversity, insects have evolved a family …
The structural basis of odorant recognition in insect olfactory receptors
J Del Mármol, MA Yedlin, V Ruta - Nature, 2021 - nature.com
Olfactory systems must detect and discriminate amongst an enormous variety of odorants.
To contend with this challenge, diverse species have converged on a common strategy in …
To contend with this challenge, diverse species have converged on a common strategy in …
Insect olfactory receptors are heteromeric ligand-gated ion channels
K Sato, M Pellegrino, T Nakagawa, T Nakagawa… - Nature, 2008 - nature.com
In insects, each olfactory sensory neuron expresses between one and three ligand-binding
members of the olfactory receptor (OR) gene family, along with the highly conserved and …
members of the olfactory receptor (OR) gene family, along with the highly conserved and …
Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors
Insect odorant receptors (ORs) comprise an enormous protein family that translates
environmental chemical signals into neuronal electrical activity. These heptahelical …
environmental chemical signals into neuronal electrical activity. These heptahelical …
orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET
Female mosquitoes of some species are generalists and will blood-feed on a variety of
vertebrate hosts, whereas others display marked host preference. Anopheles gambiae and …
vertebrate hosts, whereas others display marked host preference. Anopheles gambiae and …
A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor
M Pellegrino, N Steinbach, MC Stensmyr, BS Hansson… - Nature, 2011 - nature.com
Blood-feeding insects such as mosquitoes are efficient vectors of human infectious diseases
because they are strongly attracted by body heat, carbon dioxide and odours produced by …
because they are strongly attracted by body heat, carbon dioxide and odours produced by …
A unified nomenclature system for the insect olfactory coreceptor
LB Vosshall, BS Hansson - Chemical senses, 2011 - academic.oup.com
We propose a revised nomenclature for the insect olfactory coreceptor variously named
''Or83b,''''Or1,''''Or2,''and ''Or7.''This gene appears to be functionally orthologous across all …
''Or83b,''''Or1,''''Or2,''and ''Or7.''This gene appears to be functionally orthologous across all …
Towards an understanding of the structural basis for insect olfaction by odorant receptors
C Carraher, J Dalziel, MD Jordan, DL Christie… - Insect Biochemistry and …, 2015 - Elsevier
Insects have co-opted a unique family of seven transmembrane proteins for odour sensing.
Odorant receptors are believed to have evolved from gustatory receptors somewhere at the …
Odorant receptors are believed to have evolved from gustatory receptors somewhere at the …
Distinct activity-gated pathways mediate attraction and aversion to CO2 in Drosophila
Carbon dioxide is produced by many organic processes and is a convenient volatile cue for
insects that are searching for blood hosts, flowers, communal nests, fruit and wildfires …
insects that are searching for blood hosts, flowers, communal nests, fruit and wildfires …
Functional agonism of insect odorant receptor ion channels
In insects, odor cues are discriminated through a divergent family of odorant receptors
(ORs). A functional OR complex consists of both a conventional odorant-binding OR and a …
(ORs). A functional OR complex consists of both a conventional odorant-binding OR and a …