Cryo-EM structure of the insect olfactory receptor Orco

JA Butterwick, J Del Mármol, KH Kim, MA Kahlson… - Nature, 2018 - nature.com
The olfactory system must recognize and discriminate amongst an enormous variety of
chemicals in the environment. To contend with such diversity, insects have evolved a family …

The structural basis of odorant recognition in insect olfactory receptors

J Del Mármol, MA Yedlin, V Ruta - Nature, 2021 - nature.com
Olfactory systems must detect and discriminate amongst an enormous variety of odorants.
To contend with this challenge, diverse species have converged on a common strategy in …

Insect olfactory receptors are heteromeric ligand-gated ion channels

K Sato, M Pellegrino, T Nakagawa, T Nakagawa… - Nature, 2008 - nature.com
In insects, each olfactory sensory neuron expresses between one and three ligand-binding
members of the olfactory receptor (OR) gene family, along with the highly conserved and …

Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors

TA Hopf, S Morinaga, S Ihara, K Touhara… - Nature …, 2015 - nature.com
Insect odorant receptors (ORs) comprise an enormous protein family that translates
environmental chemical signals into neuronal electrical activity. These heptahelical …

orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET

M DeGennaro, CS McBride, L Seeholzer, T Nakagawa… - Nature, 2013 - nature.com
Female mosquitoes of some species are generalists and will blood-feed on a variety of
vertebrate hosts, whereas others display marked host preference. Anopheles gambiae and …

A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor

M Pellegrino, N Steinbach, MC Stensmyr, BS Hansson… - Nature, 2011 - nature.com
Blood-feeding insects such as mosquitoes are efficient vectors of human infectious diseases
because they are strongly attracted by body heat, carbon dioxide and odours produced by …

A unified nomenclature system for the insect olfactory coreceptor

LB Vosshall, BS Hansson - Chemical senses, 2011 - academic.oup.com
We propose a revised nomenclature for the insect olfactory coreceptor variously named
''Or83b,''''Or1,''''Or2,''and ''Or7.''This gene appears to be functionally orthologous across all …

Towards an understanding of the structural basis for insect olfaction by odorant receptors

C Carraher, J Dalziel, MD Jordan, DL Christie… - Insect Biochemistry and …, 2015 - Elsevier
Insects have co-opted a unique family of seven transmembrane proteins for odour sensing.
Odorant receptors are believed to have evolved from gustatory receptors somewhere at the …

Distinct activity-gated pathways mediate attraction and aversion to CO2 in Drosophila

F van Breugel, A Huda, MH Dickinson - Nature, 2018 - nature.com
Carbon dioxide is produced by many organic processes and is a convenient volatile cue for
insects that are searching for blood hosts, flowers, communal nests, fruit and wildfires …

Functional agonism of insect odorant receptor ion channels

PL Jones, GM Pask, DC Rinker… - Proceedings of the …, 2011 - National Acad Sciences
In insects, odor cues are discriminated through a divergent family of odorant receptors
(ORs). A functional OR complex consists of both a conventional odorant-binding OR and a …