We are facing a revival of the strategy to counteract obesity and associated metabolic
disorders by inducing thermogenesis mediated by mitochondrial uncoupling protein-1 …

Energy balance to prevent the development of obesity is dependent on energy expenditure.
Although physical activity is the dominant mechanism for dissipating excess energy, a …

Uncoupling protein 1 (UCP1), is a unique mitochondrial membranous protein devoted to
adaptive thermogenesis, a specialized function performed by brown adipocytes. Whereas …

Thermogenesis in brown adipocytes, conferred by mitochondrial uncoupling protein 1 (UCP
1), is receiving great attention because metabolically active brown adipose tissue may …

Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat
production in classical brown fat and the newly identified beige or brite fat. Thermogenesis …

The phenomenon of white fat" browning," in which certain white adipose tissue depots
significantly increase gene expression for the uncoupling protein UCP1 and thus …

Obesity-related increase in body fat mass is a risk factor for many diseases, including type 2
diabetes. Controlling adiposity by targeted modulation of adipocyte enzymes could offer an …

Exactly 50 years ago, I was a post‐doc in the laboratory of Olov Lindberg in Stockholm
measuring fatty acid oxidation by mitochondria isolated from thermogenic brown adipose …

Brown and beige adipocytes are characterised as expressing the unique mitochondrial
uncoupling protein (UCP) 1 for which the primary stimulus in vivo is cold exposure. The …

To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the
thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was …