The number of individuals with the sickle cell trait exceeds 300 million worldwide, making
sickle cell disease one of the most common monogenetic diseases globally. Because of the …

Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn
screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly …

Sickle cell disease (SCD) is a very devastating condition caused by an autosomal recessive
inherited haemoglobinopathy. This disease affects millions of peoples globally which results …

Sickle cell trait occurs in approximately 300 million people worldwide, with the highest
prevalence of approximately 30% to 40% in sub-Saharan Africa. Long considered a benign …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Sickle cell disease (SCD) is a genetic blood disorder caused by abnormal hemoglobin that
damages and deforms red blood cells (RBCs). The abnormal red cells break down, causing …

Sickle cell disease (SCD) is the most common hereditary disorder and affects 30 million
people worldwide. Advances in science have improved overall survival in patients with SCD …

Sickle cell trait (SCT), the heterozygous state of the sickle hemoglobin beta globin gene
(HbAS) is carried by as many as 100 million individuals including up to 25% of the …

The sickle cell gene is pleiotropic in nature. Although it is a single gene mutation, it has
multiple phenotypic expressions that constitute the complications of sickle cell disease. The …

Sickle cell anemia is a life-threatening disease, and the most common genetic disease in the
world. The prevalence of sickle cell anemia in Sweden is unknown. Sickle cell anemia is an …