Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …

We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects
on both ventricular and vascular performance in evolving heart failure (HF), thereby …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

Aims Oxidative stress, ie imbalance between reactive oxygen species (ROS) and antioxidant
defences, contributes to the progression of chronic heart failure (CHF). Acute inhibition of …

Although interactions between superoxide () and nitric oxide underlie many physiologic and
pathophysiologic processes, regulation of this crosstalk at the enzymatic level is poorly …

Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …

Myocardial oxidative stress and Ca2+ overload induced by ischemia-reperfusion may be
involved in the development and progression of myocardial dysfunction in heart failure …

Xanthine oxidoreductase (XOR) is increased in the left ventricle (LV) of humans with volume
overload (VO), and mitochondrial inhibition of the respiratory chain occurs in animal models …

Reactive oxygen species, in particular superoxide, have been closely linked to the
underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates …