A model 450 million years in the making: zebrafish and vertebrate immunity

SA Renshaw, NS Trede - Disease models & mechanisms, 2012 - journals.biologists.com
Since its first splash 30 years ago, the use of the zebrafish model has been extended from a
tool for genetic dissection of early vertebrate development to the functional interrogation of …

Host-pathogen interactions made transparent with the zebrafish model

AH Meijer, HP Spaink - Current drug targets, 2011 - ingentaconnect.com
The zebrafish holds much promise as a high-throughput drug screening model for immune-
related diseases, including inflammatory and infectious diseases and cancer. This is due to …

Immunology and zebrafish: spawning new models of human disease

ND Meeker, NS Trede - Developmental & Comparative Immunology, 2008 - Elsevier
The zebrafish has emerged as a powerful new vertebrate model of human disease. Initially
prominent in developmental biology, the zebrafish has now been adopted into varied fields …

[HTML][HTML] Pathogen recognition and activation of the innate immune response in zebrafish

M van der Vaart, HP Spaink, AH Meijer - Advances in hematology, 2012 - hindawi.com
The zebrafish has proven itself as an excellent model to study vertebrate innate immunity. It
presents us with possibilities for in vivo imaging of host-pathogen interactions which are …

[PDF][PDF] The use of zebrafish to understand immunity

NS Trede, DM Langenau, D Traver, AT Look, LI Zon - Immunity, 2004 - cell.com
For decades immunologists have relied heavily on the mouse model for their experimental
designs. With the realization of the important role innate immunity plays in orchestrating …

Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish

EE Rosowski - Disease models & mechanisms, 2020 - journals.biologists.com
The specific roles of the two major innate immune cell types–neutrophils and macrophages–
in response to infection and sterile inflammation are areas of great interest. The larval …

Zebrafish: model for the study of inflammation and the innate immune response to infectious diseases

B Novoa, A Figueras - Current topics in innate immunity II, 2012 - Springer
The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to
study vertebrate development and hematopoiesis and recently, it has been adopted into …

[HTML][HTML] The zebrafish as a model to study intestinal inflammation

S Brugman - Developmental & Comparative Immunology, 2016 - Elsevier
Starting out as a model for developmental biology, during the last decade, zebrafish have
also gained the attention of the immunologists and oncologists. Due to its small size, high …

Host–microbe interactions in the developing zebrafish

M Kanther, JF Rawls - Current opinion in immunology, 2010 - Elsevier
The amenability of the zebrafish to in vivo imaging and genetic analysis has fueled
expanded use of this vertebrate model to investigate the molecular and cellular foundations …

[HTML][HTML] Feed, microbiota, and gut immunity: using the zebrafish model to understand fish health

A López Nadal, W Ikeda-Ohtsubo, D Sipkema… - Frontiers in …, 2020 - frontiersin.org
Aquafeed companies aim to provide solutions to the various challenges related to nutrition
and health in aquaculture. Solutions to promote feed efficiency and growth, as well as …