Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with
prominent skeletal, ocular, and cardiovascular manifestations. Aortic aneurysm and …

Background—The primary cause of early death in untreated Marfan syndrome (MFS)
patients is aortic dilatation and dissection. Methods and Results—We investigated whether …

Objectives Marfan syndrome is an autosomal dominant inherited disorder of connective
tissue. The vascular complications of Marfan syndrome have the biggest impact on life …

Background: Occurrence of disease complications in the abdominal aorta in Marfan
syndrome, a connective tissue disorder caused by mutations in the gene encoding fibrillin-1 …

Marfan syndrome is associated with early death due to aortic aneurysm. The condition is
caused by mutations in the gene (FBN1) encoding fibrillin-1, a major constituent of …

About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …

Objective—Marfan's syndrome is characterized by the formation of ascending aortic
aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic …

Background Development of thoracic aortic aneurysms is the most significant clinical
phenotype in patients with Marfan syndrome. An inflammatory response has been described …

Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome
(MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …

Background: Marfan syndrome (MFS), an inherited disorder of connective tissue
characterized by abnormalities in the skeletal, ocular, and cardiovascular systems, is caused …