Rationale: The pathogenesis of pulmonary arterial hypertension (PAH) remains unclear. The
4 microRNAs representing the miR-143 and miR-145 stem loops are genomically clustered …

Rationale: Despite improved understanding of the underlying genetics, pulmonary arterial
hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary …

Development of the vascular disease pulmonary hypertension (PH) involves disparate
molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately …

Rationale: Recent studies suggest that microRNAs (miRNAs) play important roles in
regulation of pulmonary artery smooth muscle cell (PASMC) phenotype and are implicated …

Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and
reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Because …

Pulmonary hypertension (PH) is a complex disorder, spanning several known vascular cell
types. Recently, we identified the microRNA-130/301 (miR-130/301) family as a regulator of …

Rationale: There is a continued need for investigating the roles of microRNAs and their
targets on the pathogenesis of pulmonary arterial hypertension (PAH) vascular remodeling …

Rationale: Pulmonary hypertensive remodeling is characterized by excessive proliferation,
migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts …

Rationale: MicroRNAs (miRs) control various cellular processes in tissue homeostasis and
disease by regulating gene expression on the posttranscriptional level. Recently, it was …

MicroRNAs (miRNAs) were recently reported to play an important role in the pathogenesis of
pulmonary arterial hypertension (PAH), but it is not clear which miRNAs are important or …