Context: Poorly differentiated carcinomas represent an aggressive group of thyroid tumors
with controversial classification placement and poorly understood pathogenesis. Molecular …

Background: Molecular markers associated with thyroid malignancy are increasingly being
used as differential diagnostic tools for thyroid nodules. However, little has been reported …

Genetic predictors of outcome are reviewed in the context of a disease–cancer–that can be
(too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has …

This review describes the gene expression profile changes associated with the presence of
different mutations that contribute to thyroid cell carcinogenesis. The results are discussed in …

Purpose: ras oncogenic activation has long been demonstrated in thyroid carcinomas of
follicular cell derivation, but no consistent relationship has been shown between mutations …

OBJECTIVE Mutations at codons 12, 13 or 61 of ras which result in constitutive activation
occur frequently in human malignancies. There have been varied reports on their …

The histological differentiation of thyroid carcinoma is known to correlate with prognosis.
Ras oncogene mutations, which have been identified in various human cancers, have been …

Background Activating point mutations of the RAS gene (NRAS, HRAS, and KRAS) can be
seen in benign and malignant thyroid tumors; among these, NRAS mutations are more …

Context: Thyroid cancer incidence rates in the United States and globally have increased
steadily over the last 40 years, primarily due to a tripling of the incidence of papillary thyroid …

Summary Purpose BRAF V600E mutation represents the most common oncogenic event in
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …