RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact
M Volante, I Rapa, M Gandhi, G Bussolati… - The Journal of …, 2009 - academic.oup.com
Context: Poorly differentiated carcinomas represent an aggressive group of thyroid tumors
with controversial classification placement and poorly understood pathogenesis. Molecular …
with controversial classification placement and poorly understood pathogenesis. Molecular …
RAS Mutations, and RET/PTC and PAX8/PPAR-gamma Chromosomal Rearrangements Are Also Prevalent in Benign Thyroid Lesions: Implications Thereof and A …
A Najafian, S Noureldine, F Azar, C Atallah, G Trinh… - Thyroid, 2017 - liebertpub.com
Background: Molecular markers associated with thyroid malignancy are increasingly being
used as differential diagnostic tools for thyroid nodules. However, little has been reported …
used as differential diagnostic tools for thyroid nodules. However, little has been reported …
ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome
C Tavares, M Melo… - European journal of …, 2016 - academic.oup.com
Genetic predictors of outcome are reviewed in the context of a disease–cancer–that can be
(too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has …
(too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has …
[HTML][HTML] Gene expression profile of human thyroid cancer in relation to its mutational status
D Rusinek, S Szpak-Ulczok… - Journal of molecular …, 2011 - jme.bioscientifica.com
This review describes the gene expression profile changes associated with the presence of
different mutations that contribute to thyroid cell carcinogenesis. The results are discussed in …
different mutations that contribute to thyroid cell carcinogenesis. The results are discussed in …
ras Mutations Are Associated With Aggressive Tumor Phenotypes and Poor Prognosis in Thyroid Cancer
G Garcia-Rostan, H Zhao, RL Camp… - Journal of Clinical …, 2003 - ascopubs.org
Purpose: ras oncogenic activation has long been demonstrated in thyroid carcinomas of
follicular cell derivation, but no consistent relationship has been shown between mutations …
follicular cell derivation, but no consistent relationship has been shown between mutations …
Prevalence of Ras mutations in thyroid neoplasia
CT Esapa, SJ Johnson, P Kendall‐Taylor… - Clinical …, 1999 - Wiley Online Library
OBJECTIVE Mutations at codons 12, 13 or 61 of ras which result in constitutive activation
occur frequently in human malignancies. There have been varied reports on their …
occur frequently in human malignancies. There have been varied reports on their …
Role of ras mutation in the progression of thyroid carcinoma of follicular epithelial origin
N Motoi, A Sakamoto, T Yamochi, H Horiuchi… - … -Research and Practice, 2000 - Elsevier
The histological differentiation of thyroid carcinoma is known to correlate with prognosis.
Ras oncogene mutations, which have been identified in various human cancers, have been …
Ras oncogene mutations, which have been identified in various human cancers, have been …
RAS mutation and associated risk of malignancy in the thyroid gland: An FNA study with cytology‐histology correlation
SM Gilani, R Abi‐Raad, J Garritano, G Cai… - Cancer …, 2022 - Wiley Online Library
Background Activating point mutations of the RAS gene (NRAS, HRAS, and KRAS) can be
seen in benign and malignant thyroid tumors; among these, NRAS mutations are more …
seen in benign and malignant thyroid tumors; among these, NRAS mutations are more …
The Increase in Thyroid Cancer Incidence During the Last Four Decades Is Accompanied by a High Frequency of BRAF Mutations and a Sharp Increase in RAS …
Context: Thyroid cancer incidence rates in the United States and globally have increased
steadily over the last 40 years, primarily due to a tripling of the incidence of papillary thyroid …
steadily over the last 40 years, primarily due to a tripling of the incidence of papillary thyroid …
BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma
AM Costa, A Herrero, MF Fresno… - Clinical …, 2008 - Wiley Online Library
Summary Purpose BRAF V600E mutation represents the most common oncogenic event in
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …
相关搜索
- ras mutations thyroid carcinomas
- ras mutations prognostic impact
- thyroid carcinomas prognostic impact
- ras mutations ret ptc
- ras mutations braf oncoprotein
- ras mutations tumor phenotypes
- ras mutations ppar gamma
- cytology histology ras mutation
- ras mutations chromosomal rearrangements
- ras mutations sharp increase
- associated risk ras mutation
- ras mutations high prevalence
- thyroid cancer poor prognosis
- braf mutation thyroid carcinoma
- ras mutations thyroid neoplasia
- ras mutations thyroid lesions