The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity

P Sikiric, A Boban Blagaic, S Strbe… - Pharmaceuticals, 2024 - mdpi.com
We highlight the particular aspects of the stable gastric pentadecapeptide BPC 157
pleiotropic beneficial activity (not destroyed in human gastric juice, native and stable in …

Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications

P Sikiric, S Seiwerth, R Rucman… - Current …, 2016 - ingentaconnect.com
Background: Brain-gut interaction involves, among others, peptidergic growth factors which
are native in GI tract and have strong antiulcer potency and thus could from periphery …

Stable gastric pentadecapeptide BPC 157: Prompt particular activation of collateral pathways

P Sikiric, S Gojkovic, M Knezevic… - Current medicinal …, 2023 - ingentaconnect.com
[3-17]. Progressive venous and arterial thrombosis, both peripherally and centrally (in the
Virchow causeconsequence triad, evidencing counteracted stasis and recovered …

Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity

P Sikirić, S Seiwerth, Ž Grabarević, R Ručman… - Digestive diseases and …, 1996 - Springer
Very recently, the integrity of capsaicin somatosensory neurons and their protection were
suggested to be related to the activity in nociception of a newly discovered 15-amino acid …

Stable gastric pentadecapeptide BPC 157 and striated, smooth, and heart muscle

M Staresinic, M Japjec, H Vranes, A Prtoric, H Zizek… - Biomedicines, 2022 - mdpi.com
First, we review the definitively severed myotendinous junction and recovery by the
cytoprotective stable gastric pentadecapeptide BPC 157 therapy, its healing that might …

Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and …

P Sikiric, S Seiwerth, L Brcic, AB Blagaic, I Zoricic… - …, 2006 - Springer
Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, safe in clinical trials
for inflammatory bowel disease (PL 10, PLD 116, PLD 14736, Pliva, Croatia)) has a …

Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats

N Jelovac, P Sikiric, R Rucman, M Petek… - European journal of …, 1999 - Elsevier
A gastric pentadecapeptide, BPC 157, with the amino acid sequence, Gly–Glu–Pro–Pro–Pro–
Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val, MW 1419, known to have a variety of …

Stress in gastrointestinal tract and stable gastric pentadecapeptide BPC 157. Finally, do we have a solution?

P Sikiric, S Seiwerth, R Rucman… - Current …, 2017 - ingentaconnect.com
Selye's syndrome produced by diverse nocuous agents and “response to damage as such”
means Selye's stress triad in stress coping response to reestablish homeostasis. Logically …

Stable gastric pentadecapeptide BPC 157 may recover brain–gut axis and gut–brain axis function

P Sikiric, S Gojkovic, I Krezic, IM Smoday, L Kalogjera… - Pharmaceuticals, 2023 - mdpi.com
Conceptually, a wide beneficial effect, both peripherally and centrally, might have been
essential for the harmony of brain–gut and gut–brain axes' function. Seen from the original …

Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions

S Ilic, D Drmic, S Franjic, D Kolenc, M Coric, L Brcic… - Life sciences, 2011 - Elsevier
AIMS: We attempted to fully antagonize the extensive toxicity caused by NSAIDs (using
diclofenac as a prototype). MAIN METHODS: Herein, we used the stable gastric …