Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the
underlying mechanisms are enigmatic. Here, we report that mechanical pain hypersensitivity …

Inhibitory synaptic transmission in the dorsal horn (DH) of the spinal cord plays an important
role in the modulation of nociceptive messages because pharmacological blockade of …

Growing evidence demonstrates circadian rhythms of pain hypersensitivity in various
chronic disorders. In chemotherapy-induced peripheral neuropathy (CIPN), agents such as …

Mechanisms associated with cyclin-dependent kinase 5 (Cdk5)-mediated heat hyperalgesia
induced by inflammation remain undefined. This study was designed to examine whether …

The importance of a neuroinflammatory response to the development and maintenance of
inflammatory and neuropathic pain have been highlighted in recent years. Inflammatory …

Background: The mechanisms underlying cyclin-dependent kinase 5 (Cdk5)-mediated
thermal hyperalgesia induced by inflammation remain poorly understood. In the present …

There is growing recognition that psychological stress influences pain. Hormones that
comprise the physiological response to stress (eg, corticosterone; CORT) may interact with …

Peripheral inflammation induces persistent central sensitization characterized by
mechanical allodynia and heat hyperalgesia that are mediated by distinct mechanisms …

Insomnia, depression, and anxiety disorder are common problems for people with
neuropathic pain. In this study, mild noxious heat stimuli increased the duration and number …

We have been studying the role of ATP receptors in pain and already reported that activation
of P2X2/3 heteromeric channel/receptor in primary sensory neurons causes acutely tactile …