Purpose CFD provides a powerful approach to evaluate the deposition of pharmaceutical
aerosols; however, previous studies have not compared CFD results of deposition …

In order to answer the question “what research remains to be done?” we review the current
state of the art in pharmaceutical aerosol deposition modeling and explore possible in vivo …

Background: The objective of this study was to compare aerosol deposition predictions of a
new whole-airway CFD model with available in vivo data for a dry powder inhaler (DPI) …

Previous studies have demonstrated that factors such as airway wall motion, inhalation
waveform, and geometric complexity influence the deposition of aerosols in the alveolar …

In this study, a new computational fluid dynamics (CFD) modeling approach for
pharmaceutical aerosols is further developed by evaluating the effects of turbulence …

Purpose Deposition characteristics of MDI and DPI aerosols were compared throughout the
conducting airways for the first time using a combination of in vitro experiments and a newly …

The extrathoracic oral airway is not only a major mechanical barrier for pharmaceutical
aerosols to reach the lung but also a major source of variability in lung deposition. Using …

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

Conventional in vitro tests to assess the aerodynamic particle size distribution (APSD) from
inhaler devices use simple right-angle inlets (“mouth-throats”, MTs) to cascade impactors …

While a number of studies have considered the dynamics of ambient or environmental
particles in the respiratory tract, far fewer have evaluated the transport and deposition of …