Background: Recent studies have demonstrated highly variable blood concentrations of
piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in critically ill …

The aim of the current study was to develop and validate a robust multi-analyte high
performance liquid chromatography tandem mass spectrometry (HPLC–MS/MS) method for …

A large variation in the levels of different ß‐lactams and other antibiotics used in critically ill
patients has been documented. The aim of this study is to establish and validate a fast, ultra …

Therapeutic drug monitoring is a cornerstone of antibacterial therapy, especially in an era of
increasing antibacterial resistance in individualizing antimicrobial therapy. Liquid …

Antibiotic therapy is a crucial aspect of the management of hospitalized patients, however,
current standard dosing protocols have been shown to often attain inadequate plasmatic …

Background: Adequate antibiotic treatment is a prerequisite for the successful treatment of
systemic infections. Based on accumulating scientific evidence, a fixed dosage regimen can …

Background: Therapeutic drug monitoring (TDM) is increasingly used to optimize the dosing
of beta-lactam antibiotics in critically ill patients. However, beta-lactams are inherently …

There is strong evidence in literature supporting the benefit of monitoring plasma
concentrations of β-lactam antibiotics in the critically ill to ensure appropriateness of dosing …

Contemporary β-lactam antibiotic dosing is debatable in severely ill patients, since the
occurrence of pathophysiological changes in critical illness can result in great inter …

Background Optimizing antimicrobial therapy to attain drug exposure that limits the
emergence of resistance, effectively treats the infection, and reduces the risk of side effects …