Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from α-particle irradiated to …

EI Azzam, SM De Toledo… - Proceedings of the …, 2001 - National Acad Sciences
It has generally been considered that important biological effects of ionizing radiation arise
as a direct consequence of DNA damage occurring in irradiated cells. We have examined …

Expression of CONNEXIN43 Is Highly Sensitive to Ionizing Radiation and Other Environmental Stresses

EI Azzam, SM De Toledo, JB Little - Cancer research, 2003 - AACR
To gain a greater understanding of the mechanisms underlying the cellular responses to low-
dose ionizing radiation, gene expression profiles were examined by microarray analysis of …

Cellular radiation effects and the bystander response

JB Little - … Research/Fundamental and Molecular Mechanisms of …, 2006 - Elsevier
This report reviews briefly some of the findings reported over the past 2 years that enhance
our understanding of the radiation-induced bystander effect. These developments include …

Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts

C Shao, Y Furusawa, M Aoki, K Ando - Radiation research, 2003 - meridian.allenpress.com
Abstract Shao, C., Furusawa, Y., Aoki, M. and Ando, K. Role of Gap Junctional Intercellular
Communication in Radiation-Induced Bystander Effects in Human Fibroblasts. Radiat. Res …

Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect

EI Azzam, SM De Toledo, JB Little - Oncogene, 2003 - nature.com
Evidence accumulated over the past two decades has indicated that exposure of cell
populations to ionizing radiation results in significant biological effects occurring in both the …

Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles

EI Azzam, SM De Toledo, T Gooding… - Radiation …, 1998 - meridian.allenpress.com
We demonstrate by western analysis that the expression levels of TP53 (formerly known as
p53), CDKN1A (formerly known as), CDC2 (formerly known as), CCNB1 (cyclin B1) and …

Radiation risk to low fluences of α particles may be greater than we thought

H Zhou, M Suzuki… - Proceedings of the …, 2001 - National Acad Sciences
Based principally on the cancer incidence found in survivors of the atomic bombs dropped in
Hiroshima and Nagasaki, the International Commission on Radiation Protection (ICRP) and …

Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: the impact of radiation quality

N Autsavapromporn, M Suzuki… - Radiation …, 2013 - meridian.allenpress.com
Understanding the mechanisms underlying the bystander effects of low doses/low fluences
of low-or high-linear energy transfer (LET) radiation is relevant to radiotherapy and radiation …

The bystander response in C3H 10T½ cells: the influence of cell-to-cell contact

SA Mitchell, G Randers-Pehrson… - Radiation …, 2004 - meridian.allenpress.com
Abstract Mitchell, SA, Randers-Pehrson, G., Brenner, DJ and Hall, EJ The Bystander
Response in C3H 10T½ Cells: The Influence of Cell-to-Cell Contact. Radiat. Res. 161, 397 …

Intercellular communication of cellular stress monitored by γ-H2AX induction

JS Dickey, BJ Baird, CE Redon, MV Sokolov… - …, 2009 - academic.oup.com
When cells are exposed to ionizing radiation (IR), unexposed cells that share media with
damaged cells exhibit similar effects to irradiated cells including increased levels of DNA …