[HTML][HTML] DNA structure-specific cleavage of DNA-protein crosslinks by the SPRTN protease
HK Reinking, HS Kang, MJ Götz, HY Li, A Kieser… - Molecular cell, 2020 - cell.com
Repair of covalent DNA-protein crosslinks (DPCs) by DNA-dependent proteases has
emerged as an essential genome maintenance mechanism required for cellular viability and …
emerged as an essential genome maintenance mechanism required for cellular viability and …
A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
S Zhao, A Kieser, HY Li, HK Reinking… - Nucleic Acids …, 2021 - academic.oup.com
Repair of covalent DNA–protein crosslinks (DPCs) by the metalloprotease SPRTN prevents
genome instability, premature aging and carcinogenesis. SPRTN is specifically activated by …
genome instability, premature aging and carcinogenesis. SPRTN is specifically activated by …
[HTML][HTML] Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN
Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential
chromatin transactions, such as replication and transcription. Little was known about DPC …
chromatin transactions, such as replication and transcription. Little was known about DPC …
[HTML][HTML] Mechanisms and regulation of DNA-protein crosslink repair during DNA replication by SPRTN protease
M Perry, G Ghosal - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are
covalently crosslinked to the DNA by the action of variety of agents like reactive oxygen …
covalently crosslinked to the DNA by the action of variety of agents like reactive oxygen …
[HTML][HTML] Replication-coupled DNA-protein crosslink repair by SPRTN and the proteasome in Xenopus egg extracts
NB Larsen, AO Gao, JL Sparks, I Gallina, RA Wu… - Molecular cell, 2019 - cell.com
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
Function and evolution of the DNA-protein crosslink proteases Wss1 and SPRTN
HK Reinking, K Hofmann, J Stingele - DNA repair, 2020 - Elsevier
Covalent DNA-protein crosslinks (DPCs) are highly toxic DNA adducts, which interfere with
faithful DNA replication. The proteases Wss1 and SPRTN degrade DPCs and have emerged …
faithful DNA replication. The proteases Wss1 and SPRTN degrade DPCs and have emerged …
[HTML][HTML] The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are
covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer …
covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer …
DNA–protein crosslinks and their resolution
P Weickert, J Stingele - Annual Review of Biochemistry, 2022 - annualreviews.org
Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …
essential chromatin processes such as transcription or replication. This review strives to …
DNA–protein crosslink repair: proteases as DNA repair enzymes
J Stingele, B Habermann, S Jentsch - Trends in biochemical sciences, 2015 - cell.com
DNA–protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with
DNA transactions. The recent discovery of a yeast protease that processes DPCs …
DNA transactions. The recent discovery of a yeast protease that processes DPCs …
Isolation and detection of DNA–protein crosslinks in mammalian cells
I Torrecilla, A Ruggiano, K Kiianitsa… - Nucleic Acids …, 2024 - academic.oup.com
DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …
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