CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …

DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …

Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …

Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew,
predisposes DNA sequences toward R-loop formation upon transcription. Previous work …

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base
composition and high density of CpG dinucleotides,. Most human gene promoters are …

CpG islands (CGI) are genomic regions associated with gene promoters and involved in
gene expression regulation. Despite their high CpG content and unlike bulk genomic DNA …

The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …

In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with∼
80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with …

The majority of mammalian promoters are CpG islands; regions of high CG density that
require protection from DNA methylation to be functional. Importantly, how sequence …