Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although
several molecular mechanisms and pathways have been identified to be involved in aortic …

Introduction Extracellular matrix degradation is a hallmark of abdominal aortic aneurysm
(AAA). Among proteases that are capable of degrading extracellular matrix are a disintegrin …

SUMMARY Background: Disintegrin-like and Metalloproteinase with Thrombospondin Motifs
(ADAMTS) proteins that are fundamentally located in the extracellular matrix (ECM) have …

Extracellular matrix (ECM) in the vascular wall is a highly dynamic structure composed of a
set of different molecules such as elastins, collagens, fibronectin (Fn), laminins …

Objectives: The a disintegrin and metalloprotease (ADAM) family of metalloproteases
possesses a proteolytic function and activates various inflammatory factors. Their expression …

Objective: ADAM (a disintegrin and metalloproteinase) 15—a membrane-bound
metalloprotease from the ADAM (disintegrin and metalloproteinase) family—has been linked …

Objective—Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is
accompanied by changes in the structure and composition of the aortic ECM (extracellular …

Sporadic aortic aneurysm and dissections (AADs) are common vascular diseases that carry
a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with …

Abstract A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and
Metalloproteinase with Thrombospondin Motifs (ADAMTS) are two closely related families of …

Abstract A Disintegrin and Metalloproteinase (ADAM) is a family of proteolytic enzymes that
possess sheddase function and regulate shedding of membrane-bound proteins, growth …